Infantile Tremor Syndrome Followed by West Syndrome: Effect or Continuation of Spectrum?
| Autor: | Chandrika Azad, Vishal Guglani, Jasmine Singh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty 030309 nutrition & dietetics Adrenocorticotropic hormone Injections Intramuscular 03 medical and health sciences 0302 clinical medicine Adrenocorticotropic Hormone Tremor medicine Humans Brain magnetic resonance imaging Vitamin B12 Child 0303 health sciences medicine.diagnostic_test business.industry Epileptic encephalopathy Brain Infant Vitamin B 12 Deficiency Magnetic resonance imaging West Syndrome Syndrome medicine.disease Magnetic Resonance Imaging Vitamin B 12 Malnutrition Infectious Diseases Pediatrics Perinatology and Child Health Etiology business Spasms Infantile 030217 neurology & neurosurgery |
| Zdroj: | Journal of Tropical Pediatrics. 66:556-560 |
| ISSN: | 1465-3664 |
| Popis: | Background Infantile tremor syndrome (ITS) is a nutritional deficiency syndrome, frequently reported from the Indian subcontinent caused by vitamin B12 deficiency. The West syndrome (WS), on the other hand, is a type of epileptic encephalopathy with variable etiology. Case Series We present a series of five children who presented with symptoms consistent with ITS and received standard intramuscular vitamin B12 therapy to which good response was observed. All these children were readmitted with WS with a time lag varying from 2 to 12 months. Magnetic resonance imaging brain and metabolic screen were within normal limits. Three out of five patients responded well to adrenocorticotropic hormone (ACTH), remaining two required additional drugs. We hypothesize that WS could have developed after ITS due to developmental desynchronization. Conclusion In the Indian scenario, it is particularly important to be aware of appearance of WS after ITS, because of high prevalence of ITS and devastating nature of WS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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