Overexpression of Fas/CD95 and Fas‐Induced Apoptosis in a Patient with Idiopathic CD4+ T Lymphocytopenia
| Autor: | E. Counillon, Alain Bernard, Jean-Philippe Breittmayer, Ghislaine Bernard-Pomier, Pierre Dellamonica, Pierre-Marie Roger |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Microbiology (medical) Mycobacterium xenopi medicine.drug_class Lymphocyte T cell Mycobacterium Infections Nontuberculous Apoptosis HIV Infections Monoclonal antibody Reference Values hemic and lymphatic diseases medicine Humans Lymphocytes fas Receptor T-Lymphocytopenia Idiopathic CD4-Positive Leukopenia business.industry Receptors Interleukin-2 hemic and immune systems T lymphocyte Middle Aged medicine.disease Fas receptor CD4 Lymphocyte Count Infectious Diseases medicine.anatomical_structure Immunology Lymphocytopenia medicine.symptom business |
| Zdroj: | Clinical Infectious Diseases. 28:1012-1016 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | The mechanisms of apoptosis have become better understood, in part with the discovery of Fas/ CD95. We report the case of a patient characterized by a decreased CD4 - T cell count and an overexpression of Fas/CD95 resulting in apoptosis. A 54-year-old man presented with disseminated Mycobacterium xenopi infection. Analysis showed CD4 + T lymphopenia. Tests for human immunodeficiency virus (HIV) types 1 and 2 were negative. We compared the patient with eight healthy controls and five HIV-infected patients in terms of the expression of Fas/CD95 and Fas-mediated apoptosis of peripheral T lymphocytes. The percent of CD95 + cells in lymphocytes was 98% for the patient, and the mean percent of CD95 + cells in lymphocytes ± SD for HIV-infected patients and healthy controls was 75% ± 16% and 36% ± 26%, respectively. The patient had a high level of spontaneous apoptosis, and apoptotic cells were all identified as being CD4 + T cells. Monoclonal antibodies to CD95 dramatically increased apoptosis of CD4 + T cells exclusively. CD4 + T lymphopenia observed in our patient correlated with an overexpression of Fas together with spontaneous and Fas-induced apoptosis. |
| Databáze: | OpenAIRE |
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