The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin
| Autor: | Nadezhda Knauer, Irina V. Mirzaeva, Irina Valentinovna Andrienko, Natalya Pronkina, Vladimir A. Kozlov, E. A. Kovalenko, Alina Aktanova, Ekaterina Pashkina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
cucurbit[7]uril
Organoplatinum Compounds Pyridines Melanoma Experimental 02 engineering and technology Pharmacology 01 natural sciences Mice chemistry.chemical_compound Cytotoxic T cell Biology (General) Spectroscopy Chemistry Imidazoles General Medicine 021001 nanoscience & nanotechnology Computer Science Applications Toxicity carboplatin supramolecular complex Female 0210 nano-technology medicine.drug Bridged-Ring Compounds QH301-705.5 Antineoplastic Agents 010402 general chemistry Article Catalysis Inorganic Chemistry In vivo medicine Animals Humans Immunologic Factors Viability assay Physical and Theoretical Chemistry QD1-999 Molecular Biology neoplasms cell viability Organic Chemistry oxaliplatin Carboplatin In vitro 0104 chemical sciences Oxaliplatin Cell culture K562 Cells |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 14 International Journal of Molecular Sciences, Vol 22, Iss 7337, p 7337 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22147337 |
| Popis: | Cucurbit[7]uril (CB[7]) is a molecular container that may form host–guest complexes with platinum(II) anticancer drugs and modulate their efficacy and safety. In this paper, we report our studies of the effect of CB[7]–oxaliplatin complex and the mixture of CB[7] and carboplatin (1:1) on viability and proliferation of a primary cell culture (peripheral blood mononuclear cells), two tumor cell lines (B16 and K562) and their activity in the animal model of melanoma. At the same time, we studied the impact of platinum (II) drugs with CB[7] on T cells and B cells in vitro. Although the stable CB[7]–carboplatin complex was not formed, the presence of cucurbit[7]uril affected the biological properties of carboplatin. In vivo, CB[7] increased the antitumor effect of carboplatin, but, at the same time, increased its acute toxicity. Compared to free oxaliplatin, its complex with CB[7] shows a greater cytotoxic effect on tumor cell lines B16 and K562, while in vivo, the effects of the free drug and encapsulated drug were comparable. However, in vivo studies also demonstrated that the encapsulation of oxaliplatin in CB[7] lowered the toxicity of the drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|