Divergent effects of D2/3 receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
| Autor: | Daina Economidou, David E. H. Theobald, Daniele Caprioli, Margarita Moreno, Adam C. Mar, Anushka B. P. Fernando, C. López-Granero, Trevor W. Robbins, Jeffrey W. Dalley, Amy Hauck Newman |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Serial reaction time
Male Impulsivity Quinpirole Pyrrolidines Dopamine Nucleus accumbens Hyperkinesis Motor Activity Naphthalenes Nucleus Accumbens Dose-Response Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Receptors Dopamine D2 medicine Dopamine D3 Reaction Time Animals Receptor 030304 developmental biology Original Investigation Pharmacology 0303 health sciences Dose-Response Relationship Drug Receptors Dopamine D2 Ventral striatum Receptors Dopamine D3 Nafadotride Rats medicine.anatomical_structure chemistry Attention Deficit Disorder with Hyperactivity Dopamine Agonists Impulsive Behavior Dopamine Antagonists medicine.symptom Drug Neuroscience 030217 neurology & neurosurgery Locomotion medicine.drug |
| Zdroj: | Psychopharmacology |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | Rationale Previously we demonstrated reduced D2/3 receptor availability in the ventral striatum of hyper-impulsive rats on the five-choice serial reaction time task (5-CSRTT). However, the anatomical locus of D2/3 receptor dysfunction in high impulsive (HI) rats is unknown. Objective In the present study, we investigated whether D2/3 receptor dysfunction in HI rats is localised to the core or shell sub-regions of the nucleus accumbens (NAcb). Methods Rats were selected for low (low impulsive, LI) and high impulsivity on the 5-CSRTT and implanted with guide cannulae targeting the NAcb core and shell. The D2/3 receptor agonist quinpirole was locally injected in the NAcb (0.1, 0.3 and 1 μg per infusion) and its effects investigated on the performance of LI and HI rats on the 5-CSRTT as well as spontaneous locomotor activity in an open field. Results Intra-NAcb core quinpirole increased premature responding in HI rats but not in LI rats. In contrast, intra-NAcb shell quinpirole strongly increased locomotor activity in HI rats, unlike LI rats. This effect was blocked by intra-NAcb shell infusions of the D2/3 receptor antagonist nafadotride (0.03 μg). However, nafadotride was ineffective in blocking the effects of intra-NAcb core quinpirole on premature responding in HI rats. Conclusions These findings indicate that impulsivity and hyperactivity are separately regulated by core and shell sub-regions of the NAcb and that HI rats show an enhanced response to D2/3 receptor activation in these regions. These results suggest that the symptom clusters of hyperactivity and impulsivity in attention-deficit hyperactivity disorder may be neurally dissociable at the level of the NAcb. Electronic supplementary material The online version of this article (doi:10.1007/s00213-013-3010-3) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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