Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats
| Autor: | Louise Ramhøj, Karen Mandrup, Ulla Hass, Terje Svingen, Marta Axelstad |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
General Neuroscience
Endocrine disruption Mammary gland Anti-androgenic Nipple retention General Medicine Development Toxicology Flame retardants General Biochemistry Genetics and Molecular Biology Anogenital distance SDG 3 - Good Health and Well-being Polybrominated diphenyl ethers Medicine General Agricultural and Biological Sciences Environmental Contamination and Remediation Developmental Biology |
| Zdroj: | Ramhøj, L, Mandrup, K, Hass, U, Svingen, T & Axelstad, M 2022, ' Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats ', PeerJ, vol. 10, 12738 . https://doi.org/10.7717/peerj.12738 PeerJ PeerJ, Vol 10, p e12738 (2022) |
| Popis: | Polybrominated diphenyl ethers (PBDEs) are legacy compounds with continued widespread human exposure. Despite this, developmental toxicity studies of DE-71, a mixture of PBDEs, are scarce and its potential for endocrine disrupting effects in vivo is not well covered. To address this knowledge gap, we carried out a developmental exposure study with DE-71. Pregnant Wistar rat dams were exposed to 0, 40 or 60 mg/kg bodyweight/day from gestation day 7 to postnatal day 16, and both sexes were examined. Developmental exposure affected a range of reproductive toxicity endpoints. Effects were seen for both male and female anogenital distances (AGD), with exposed offspring of either sex displaying around 10% shorter AGD compared to controls. Both absolute and relative prostate weights were markedly reduced in exposed male offspring, with about 40% relative to controls. DE-71 reduced mammary gland outgrowth, especially in male offspring. These developmental in vivo effects suggest a complex effect pattern involving anti-androgenic, anti-estrogenic and maybe estrogenic mechanisms depending on tissues and developmental stages. Irrespective of the specific underlying mechanisms, these in vivo results corroborate that DE-71 causes endocrine disrupting effects and raises concern for the effects of PBDE-exposure on human reproductive health, including any potential long-term consequences of disrupted mammary gland development. |
| Databáze: | OpenAIRE |
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