Inhibition of urate excretion by pyrazinoate: a micropuncture study
| Autor: | F Roch-Ramel, IM Weiner |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Lithium (medication) Diuresis Physiology (medical) Internal medicine biology.animal Pyrazinoate medicine Animals Infusions Parenteral Mannitol Carbon Radioisotopes Urate excretion biology Probenecid Chemistry Inulin Haplorhini Uric Acid Kidney Tubules Endocrinology Pyrazines Cebus albifrons Female medicine.drug |
| Zdroj: | American Journal of Physiology-Legacy Content. 229:1604-1608 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1975.229.6.1604 |
| Popis: | Anesthetized monkeys (Cebus albifrons) undergoing moderate mannitol diuresis were treated with infusions containing lithium urate to elevate the urate concentration in plasma to 45-68 mug/ml and containing the uricosuric drug, 2-nitroprobenecid, to enhance the renal clearance or urate. The urate/inulin clearance ratio was 0.55 +/- 0.03. When pyrazinoate was added to the infusion the clearance ratio fell to 0.26 +/- 0.02. Analysis of free-flow micropuncture samples revealed a major effect of pyrazinoate in the proximal tubule, although an additional, smaller action in the distal tubule could not be definitely excluded. When droplets containing [14C]urate and [3H]inulin were streaked on the surface of the left kidney more urate than inulin appeared in the urine from that kidney (but not the other) within the first 3 min after application. This "excess" excretion of urate could be largely eliminated by pretreatment with pyrazinoate. The results suggest that pyrazinoate inhibits secretion of urate in the proximal tubule. |
| Databáze: | OpenAIRE |
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