Lansoprazole-Induced Improvement of Esophageal Submucosal Injury
| Autor: | Yoshiya Tanaka, Shinichiro Mine |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
esophageal wall structure
medicine.medical_specialty Clinical Biochemistry Lansoprazole Medicine (miscellaneous) Inflammation Endoscopic ultrasonography Gastroenterology Internal medicine Submucosa medicine Reflux esophagitis endoscopic ultrasonography Nutrition and Dietetics business.industry Reflux GERD lansoprazole medicine.disease digestive system diseases medicine.anatomical_structure Serial Review Cytokine secretion medicine.symptom business medicine.drug |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| Popis: | The proton pumpvinhibitor, lansoprazole, is reported to have acid secretion inhibiting effect as well as anti-inflammatory effects such as inhibition of cytokine secretion from inflammatory cells. Clinically, excellent efficacy of lansoprazole is reported for not only gastric ulcer but also gastroesophageal reflux disease (GERD). Since GERD is categorized endoscopically into erosive esophagitis and non-erosive reflux disease, it is important to make accurate assessment of any improvement in the inflammatory process when using endoscopic ultrasonography (EUS) capable of visualizing the submucosal structure. We report here our experience in assessing the effect of treatment with lansoprazole on esophageal wall structure using EUS in patients with GERD. At baseline (before treatment), EUS showed abnormalities in the mucosa, submucosa and muscularis propria caused by inflammation, thickening of the entire esophageal wall and changes in the contractile properties of esophageal smooth muscles reflecting the effects of inflammation on the entire wall of the lower esophagus in reflux esophagitis regardless of whether it is erosive or endoscopically-negative. Treatment with lansoprazole resulted in normalization of esophageal wall structure and improvement of motility, suggesting that lansoprazole improves not only mucosal inflammation but also submucosal inflammation in GERD. |
| Databáze: | OpenAIRE |
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