An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness

Autor: Hiroki Tanaka, Yoshinori Sakurai, Yu Sanada, Minoru Suzuki, Koji Ono, Takushi Takata, Shin-ichiro Masunaga, Keizo Tano
Rok vydání: 2020
Předmět:
cancer stemness
Boron Compounds
Lung Neoplasms
Health
Toxicology and Mutagenesis
Lung metastasis
Cancer therapy
Large capacity
Apoptosis
Boron Neutron Capture Therapy
Tumor cells
Borohydrides
Ligands
Tumor heterogeneity
10B microdistribution
030218 nuclear medicine & medical imaging
Mice
03 medical and health sciences
0302 clinical medicine
Isotopes
Neoplasms
tumor heterogeneity
Regular Paper
Tumor Microenvironment
medicine
Animals
Humans
Radiology
Nuclear Medicine and imaging
Neoplasm Metastasis
Cellular Senescence
Boron
Tumor microenvironment
quiescent tumor cell
Radiation
business.industry
Therapeutic effect
Cancer
medicine.disease
Oxygen
030220 oncology & carcinogenesis
Neoplastic Stem Cells
Cancer research
AcademicSubjects/SCI00960
AcademicSubjects/MED00870
business
Neoplasm Transplantation
DNA Damage
Zdroj: Journal of Radiation Research
ISSN: 1349-9157
0449-3060
Popis: Based on our previously published reports concerning the response of quiescent (Q) tumor cell populations to boron neutron capture therapy (BNCT), the heterogeneous microdistribution of 10B in tumors, which is influenced by the tumor microenvironment and the characteristics of the 10B delivery carriers, has been shown to limit the therapeutic effect of BNCT on local tumors. It was also clarified that the characteristics of 10B-carriers for BNCT and the type of combined treatment in BNCT can also affect the potential for distant lung metastases from treated local tumors. We reviewed the findings concerning the response of Q tumor cell populations to BNCT, mainly focusing on reports we have published so far, and we identified the mode of BNCT that currently offers the best therapeutic gain from the viewpoint of both controlling local tumor and suppressing the potential for distant lung metastasis. In addition, based on the finding that oxygenated Q tumor cells showed a large capacity to recover from DNA damage after cancer therapy, the interrelationship among the characteristics in Q tumor cell populations, tumor heterogeneity and cancer stemness was also discussed.
Databáze: OpenAIRE
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