Identification and Replication of Six Loci Associated With Gallstone Disease
| Autor: | Helene Gellert‐Kristensen, Sune Fallgaard Nielsen, Stefan Stender, Anne Tybjærg-Hansen, N. Dalila, Børge G. Nordestgaard |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Complex disease Gallstones Disease Danish 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Hepatology business.industry Plasma levels medicine.disease Biobank language.human_language 030104 developmental biology Increased risk Genetic Loci Susceptibility locus language 030211 gastroenterology & hepatology business Genome-Wide Association Study |
| Zdroj: | Hepatology. 70:597-609 |
| ISSN: | 1527-3350 0270-9139 |
| DOI: | 10.1002/hep.30313 |
| Popis: | Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts. We extracted genetic associations with gallstone disease from the Global Biobank Engine (GBE), an online browser of genome-wide associations in UK Biobank participants (14,940 cases and 322,268 controls). Significant associations (P 2.5 (prevalence 1%) had a 5-fold increased risk of gallstones compared to those with a score |
| Databáze: | OpenAIRE |
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