Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus
| Autor: | Miho Yano, Kenji Kamiuchi, Takahiro Kanatsuna, Goji Hasegawa, Toshikazu Yoshikawa, Michiyo Ishii, Akane Kitamura, Naoto Nakamura, Hiroshi Obayashi |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Genotype Endocrinology Diabetes and Metabolism Polymerase Chain Reaction Nephropathy Diabetic nephropathy Endocrinology Diabetic Neuropathies Gene Frequency Reference Values Diabetes mellitus Internal Medicine medicine Humans L-Selectin Allele frequency Aged DNA Primers Polymorphism Genetic biology Base Sequence business.industry Type 2 Diabetes Mellitus DNA Middle Aged medicine.disease Diabetes Mellitus Type 2 Immunology biology.protein L-selectin Female business Polymorphism Restriction Fragment Length Kidney disease |
| Zdroj: | Journal of diabetes and its complications. 16(5) |
| ISSN: | 1056-8727 |
| Popis: | Background/aims: Glomerular infiltration with monocytes/macrophages has been implicated in the pathogenesis of diabetic nephropathy. In this study, we evaluated the relationship between the genetic polymorphism in leukocyte–endothelial adhesion molecule-1 (LECAM-1) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: We determined the frequency of the LECAM-1 P213S genotype in 102 diabetic patients with diabetic nephropathy, 90 diabetic patients with no evidence of diabetic nephropathy, and 200 healthy control individuals. Results: The frequency of the LECAM-1 213PP genotype and P allele in patients with diabetic nephropathy was significantly higher than that in patients without nephropathy (genotype 68% vs. 53%, χ 2 =6.78, P =.034; allele 83% vs. 72%, χ 2 =6.26, P =.012). The LECAM-1 P213 genotype was associated with a 1.86-fold increased risk for nephropathy independently of other risk factors. Conclusion: The data suggest that the LECAM-1 213PP genotype is a genetic risk factor for the development of nephropathy in type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
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