Sulfamethoxazole derivatives complexed with metals: a new alternative against biofilms of rapidly growing mycobacteria
| Autor: | Josiéli Demetrio Siqueira, Marli Matiko Anraku de Campos, Fallon dos Santos Siqueira, Viviane Drescher Somavilla, Vanessa da Costa Flores, Alencar Kolinski Machado, Priscila Marquezan Copetti, Vanessa Albertina Agertt, Renne de Sousa Dias, Grazielle Guidolin Rossi, Camilla Filippi dos Santos Alves, Michele Rorato Sagrillo, Davi F. Back |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Medical device Sulfamethoxazole Chemistry Biofilm Context (language use) Microbial Sensitivity Tests biochemical phenomena metabolism and nutrition Aquatic Science Antimicrobial Applied Microbiology and Biotechnology Anti-Bacterial Agents Mycobacterium Microbiology 03 medical and health sciences 030104 developmental biology Microbial resistance Metals Biofilms medicine Humans Water Science and Technology medicine.drug |
| Zdroj: | Biofouling. 34:893-911 |
| ISSN: | 1029-2454 0892-7014 |
| Popis: | Biofilms are considered important sources of infections on biomedical surfaces, and most infections involving biofilm formation are associated with medical device implants. Therefore, there is an urgent need for new antimicrobial compounds that can combat microbial resistance associated with biofilm formation. In this context, this work aimed to evaluate the antibiofilm action of sulfamethoxazole complexed with Au, Cd, Cu, Ni and Hg on rapidly growing mycobacteria (RGM), as well as to evaluate their safety through cytotoxic assays. The results demonstrate potentiation of the novel compounds in antibiofilm activity, mainly in the complex with Au, which was able to completely inhibit biofilm formation and had the capacity to destroy the biofilm at all the concentrations tested. All cytotoxic data suggest that the majority of sulfamethoxazole metallic derivatives are antimicrobial alternatives, as well as safe molecules, which could be used as potential therapeutic agents for bacterial and biofilm elimination. |
| Databáze: | OpenAIRE |
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