Association of diuretic use with increased risk for long-term post-transplantation diabetes mellitus in kidney transplant recipients
| Autor: | Sara Sokooti, Frank Klont, Sok Cin Tye, Daan Kremer, Rianne M Douwes, Gérard Hopfgartner, Robin P F Dullaart, Hiddo J L Heerspink, Stephan J L Bakker |
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| Přispěvatelé: | Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT) |
| Rok vydání: | 2022 |
| Předmět: |
BLOOD-PRESSURE
DETERMINANTS post-transplantation diabetes mellitus GLUCOSE Thiazides CALCIUM-CHANNEL BLOCKER Postoperative Complications Sodium Potassium Chloride Symporter Inhibitors Risk Factors HYDROCHLOROTHIAZIDE Diabetes Mellitus Humans Prospective Studies Diuretics Glycated Hemoglobin INSULIN-RESISTANCE Transplantation HYPERTENSION loop diuretics Kidney Transplantation Transplant Recipients ANTIHYPERTENSIVE THERAPY Nephrology TRIAL thiazide kidney transplant recipients LIPID-LOWERING TREATMENT |
| Zdroj: | Nephrology Dialysis Transplantation, 37(7), 1375-1383. Oxford University Press Nephrology Dialysis Transplantation |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Background Post-transplantation diabetes mellitus (PTDM) is a major clinical problem in kidney transplant recipients (KTRs). Diuretic-induced hyperglycaemia and diabetes have been described in the general population. We aimed to investigate whether diuretics also increase PTDM risk in KTRs. Methods We included 486 stable outpatient KTRs (with a functioning graft ≥1 year) without diabetes from a prospective cohort study. Participants were classified as diuretic users and non-users based on their medication use verified by medical records. Results At the baseline study, 168 (35%) KTRs used a diuretic (thiazide, n = 74; loop diuretic, n = 76; others, n = 18) and 318 KTRs did not use a diuretic. After 5.2 years [interquartile range (IQR) 4.0‒5.9] of follow up, 54 (11%) KTRs developed PTDM. In Cox regression analyses, diuretic use was associated with incident PTDM, independent of age, sex, fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) {hazard ratio [HR] 3.28 [95% confidence interval (CI) 1.84–5.83]; P Conclusions This study demonstrates that diuretics overall are associated with an increased risk of developing PTDM in KTRs, independent of established risk factors for PTDM development. The association was present for both thiazide and loop diuretics. |
| Databáze: | OpenAIRE |
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