Global perspectives of premature birth across the life course
| Autor: | Cally J Tann, Carrie L Williams |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Pregnancy medicine.medical_specialty business.industry Obstetrics Infant Newborn MEDLINE Infant Gestational age Gestational Age medicine.disease Article Cohort Studies Premature birth Pediatrics Perinatology and Child Health Developmental and Educational Psychology medicine Humans Premature Birth Life course approach Female business Cohort study |
| Zdroj: | The Lancet Child & Adolescent Health. 3:370-371 |
| ISSN: | 2352-4642 |
| DOI: | 10.1016/s2352-4642(19)30109-9 |
| Popis: | BACKGROUND: Breakthroughs in the treatment of preterm birth approximately 40 years ago have enabled a generation of preterm survivors to now reach mid-adulthood. Understanding their health sequelae is essential for guiding their long-term care. We conducted the first study to examine preterm birth in relation to mortality into mid-adulthood. METHODS: A national cohort study was conducted of all 4,296,814 singleton live births in Sweden in 1973–2015, who were followed up for mortality through 2017 (maximum age 45 years). Cox regression was used to examine gestational age at birth in relation to all-cause and cause-specific mortality, and co-sibling analyses assessed for potential confounding by shared familial (genetic and/or environmental) factors. FINDINGS: There were 43,916 (1·0%) deaths in 103·5 million person-years of follow-up. Gestational age at birth was inversely associated with mortality from infancy into mid-adulthood. Relative to full-term birth (39–41 weeks), adjusted hazard ratios for mortality associated with extremely preterm (22–27 weeks), very preterm (28–33 weeks), late preterm (34–36 weeks), and early term (37–38 weeks) birth were 66·14 (95% CI, 63·09–69·34), 8·67 (8·32–9·03), 2·61 (2·52–2·71), and 1·34 (1·30–1·37), respectively, at ages 0–45 years; and 2·04 (95% CI, 0·92–4·55), 1·48 (1·17–1·87), 1·22 (1·07–1·39), and 1·16 (1·08–1·25), respectively, at ages 30–45 years. Preterm birth accounted for more deaths among males than females (additive interaction, P |
| Databáze: | OpenAIRE |
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