Human cationic, pancreatic elastase in acute pancreatitis
| Autor: | Anders Borgström, Kjell Ohlsson, Hans-Olof Håkansson |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Molecular Sequence Data Clinical Biochemistry Alpha (ethology) Cations Internal medicine medicine Ascitic Fluid Humans Trypsin alpha-Macroglobulins Amino Acid Sequence Pancreatic elastase Serpins chemistry.chemical_classification Pancreatic Elastase biology Elastase Cationic polymerization Exudates and Transudates General Medicine medicine.disease Enzyme Endocrinology Pancreatitis chemistry Enzyme inhibitor alpha 1-Antitrypsin Acute Disease Amylases biology.protein Acute pancreatitis Trypsin Inhibitors |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 53:17-24 |
| ISSN: | 1502-7686 0036-5513 |
| Popis: | Immunoreactive cationic pancreatic elastase (irPE) in serum and peritoneal exudate from 8 patients with severe acute pancreatitis was found mainly in complex with alpha-1-proteinase-inhibitor (alpha 1PI). Only minor amounts of irPE were found in a molecular form corresponding to the free proenzyme. The presence of alpha-2-macroglobulin (alpha 2M)-bound, elastase-like activity in the exudates indicates that active elastase was bound to this inhibitor. The results indicate that pancreatic cationic elastase is released to some extent as active enzyme in acute pancreatitis. However, no free elastolytic activity was present in the exudates. |
| Databáze: | OpenAIRE |
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