Fast T2 gradient-spin-echo (T2-GraSE) mapping for myocardial edema quantification: first in vivo validation in a porcine model of ischemia/reperfusion
| Autor: | Valentin Fuster, María del Trigo, Rodrigo Fernández-Jiménez, Javier Sánchez-González, Jaume Aguero, Borja Ibanez, Carlos Galán-Arriola |
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| Přispěvatelé: | Instituto de Salud Carlos III, European Regional Development Fund (ERDF/FEDER), Ministerio de Economía y Competitividad (España), Fundación Jesús Serra, Fundacion Interhospitalaria de Investigacion Cardiovascular (FIC), Red de Investigación Cardiovascular (España), Fundación ProCNIC |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Time Factors Swine CONTROVERSIES Body water Myocardial Infarction Infarction TISSUE CHARACTERIZATION Imaging Edema REPERFUSION Myocardial infarction T2-mapping CMR Medicine(all) RISK Edema Cardiac Water content Radiological and Ultrasound Technology medicine.diagnostic_test CARDIAC MAGNETIC-RESONANCE Cardiology RELAXATION-TIMES medicine.symptom Cardiology and Cardiovascular Medicine INFARCTION medicine.medical_specialty Ischemia Magnetic Resonance Imaging Cine Myocardial Reperfusion Injury Body Water Predictive Value of Tests In vivo Internal medicine Image Interpretation Computer-Assisted medicine INJURY Animals Radiology Nuclear Medicine and imaging Angiology business.industry Research Myocardium AREA Reproducibility of Results Magnetic resonance imaging medicine.disease Disease Models Animal Cardiovascular magnetic resonance business |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Repisalud Instituto de Salud Carlos III (ISCIII) |
| Popis: | Background: Several T2-mapping sequences have been recently proposed to quantify myocardial edema by providing T2 relaxation time values. However, no T2-mapping sequence has ever been validated against actual myocardial water content for edema detection. In addition, these T2-mapping sequences are either time-consuming or require specialized software for data acquisition and/or post-processing, factors impeding their routine clinical use. Our objective was to obtain in vivo validation of a sequence for fast and accurate myocardial T2-mapping (T2 gradient-spin-echo [GraSE]) that can be easily integrated in routine protocols. Methods: The study population comprised 25 pigs. Closed-chest 40 min ischemia/reperfusion was performed in 20 pigs. Pigs were sacrificed at 120 min (n = 5), 24 h (n = 5), 4 days (n = 5) and 7 days (n = 5) after reperfusion, and heart tissue extracted for quantification of myocardial water content. For the evaluation of T2 relaxation time, cardiovascular magnetic resonance (CMR) scans, including T2 turbo-spin-echo (T2-TSE, reference standard) mapping and T2-GraSE mapping, were performed at baseline and at every follow-up until sacrifice. Five additional pigs were sacrificed after baseline CMR study and served as controls. Results: Acquisition of T2-GraSE mapping was significantly (3-fold) faster than conventional T2-TSE mapping. Myocardial T2 relaxation measurements performed by T2-TSE and T2-GraSE mapping demonstrated an almost perfect correlation (R-2 = 0.99) and agreement with no systematic error between techniques. The two T2-mapping sequences showed similarly good correlations with myocardial water content: R-2 = 0.75 and R-2 = 0.73 for T2-TSE and T2-GraSE mapping, respectively. Conclusions: We present the first in vivo validation of T2-mapping to assess myocardial edema. Given its shorter acquisition time and no requirement for specific software for data acquisition or post-processing, fast T2-GraSE mapping of the myocardium offers an attractive alternative to current CMR sequences for T2 quantification. This work was supported by a competitive grant from the Ministry of Economy and Competitiveness (MINECO) through the Carlos III Institute of Health -Fondo de Investigacion Sanitaria (PI13/01979)-, the Fondo Europeo de Desarrollo Regional (FEDER, RD: SAF2013-49663-EXP), and in part by the FP7-PEOPLE-2013-ITN Next generation training in cardiovascular research and innovation-Cardionext. Rodrigo Fernandez-Jimenez is recipient of a Rio Hortega fellowship from the Ministry of Economy and Competitiveness through the Instituto de Salud Carlos III, and a FICNIC fellowship from the Fundacio Jesus Serra, the Fundacion Interhospitalaria de Investigacion Cardiovascular (FIC) and the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC). Javier Sanchez-Gonzalez is an employee of Philips Healthcare. Jaume Aguero is a FP7-PEOPLE-2013-ITN-Cardionext fellow. Carlos Galan-Arriola is recipient of a ``Contrato Predoctoral de Formacion en Investigacion en Salud (PFIS), FI14/00356´´. This study forms part of a Master Research Agreement (MRA) between CNIC and Philips Healthcare. Borja Ibanez is supported by the Red de Investigacion Cardiovascular (RIC) of the Spanish Ministry of Health (RD 12/0042/0054). The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation. Sí |
| Databáze: | OpenAIRE |
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