Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats

Autor:	Jury Ju. Ivnitsky, Vladimir L. Rejniuk, Timur V. Schäfer
Rok vydání:	2011
Předmět:	Article Subject Cyclophosphamide business.industry Pharmacology Glutamine chemistry.chemical_compound Ammonia chemistry Mean Survival Time Toxicity Medicine Digestive tract Blood ammonia business Ammonium acetate Research Article medicine.drug
Zdroj:	ISRN Toxicology
ISSN:	2090-6196 2090-6188
DOI:	10.5402/2011/450875
Popis:	To estimate the influence of the digestive tract luminal ammonia pool on acute toxic effects of cyclophosphamide, the dynamics of blood ammonia, glutamine and urea level, symptoms of toxic action and the survival time have been studied in rats, intraperitoneally treated with cyclophosphamide, at the background of the gavage with non-lethal dose of ammonium acetate (12 mmol/kg, i.e., 0.35 LD50). Ammonium acetate enhanced the hyperammonaemic action of cyclophosphamide while promoting its lethal action: the mean survival time decreased 1.5, 2.1, 2.8, or 6.1 times at the background of cyclophosphamide i/p doses 200, 600, 1000, or 1400 mg/kg, respectively. Animals exposed to the combination of toxicants, manifested symptoms which were characteristic of the effect of lethal doses of ammonia salts. These data provide the evidence of the detrimental role of gastrointestinal luminal ammonia in the acute high-dose cyclophosphamide toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eae22e23cbccf07543e1c28f490ae5c https://doi.org/10.5402/2011/450875 Zobrazit plný text záznamu Plný text ve formátu PDF