Nicht-invasive molekulare Bildgebung zur Darstellung von Entzündungsprozessen des Zentralnervensystems
| Autor: | Peter Ponsaerts, Alexander Gerhard, Bertrand Tavitian, Sylvie Chalon, Adriana Maggi, Alexandra Winkeler, Herve Boutin, Michael Heneka, Vincent Camus, ELISABETTA VEGETO, Mario Quarantelli, Lars Hageman Pinborg |
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| Přispěvatelé: | Radiology and nuclear medicine, NCA - Brain Imaging, Van Der Linden, Anne-Marie, Ponsaerts, Peter, INMiND Consortium, Universitäts- und Landesbibliothek Münster |
| Rok vydání: | 2012 |
| Předmět: |
microglia
Molecular imaging Neuroimaging Inflammation Review Article Disease Biology multiple sclerosis cerebral ischemia Multiple sclerosis 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Humans ddc:610 Neuroinflammation Tissue homeostasis 030304 developmental biology 0303 health sciences Microglia Neurodegeneration Brain Alzheimer's disease Cerebral ischemia medicine.disease Alzheimer Krankheit Hirnischämie Multiple Sklerose Mikroglia molekulare Bildgebung molecular imaging 3. Good health medicine.anatomical_structure Spinal Cord Neurology Alzheimer’s disease inflammation Medicine and health Neurology (clinical) Human medicine medicine.symptom Cardiology and Cardiovascular Medicine Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism Digital.CSIC. Repositorio Institucional del CSIC instname Journal of Cerebral Blood Flow and Metabolism, 32(7), 1393-1415. Nature Publishing Group Journal of cerebral blood flow and metabolism 32 (2012): 1393–1415. doi:10.1038/jcbfm.2012.53 info:cnr-pdr/source/autori:Jacobs, Andreas H.; Tavitian, Bertrand; and the INMiND consortium/titolo:Noninvasive molecular imaging of neuroinflammation/doi:10.1038%2Fjcbfm.2012.53/rivista:Journal of cerebral blood flow and metabolism/anno:2012/pagina_da:1393/pagina_a:1415/intervallo_pagine:1393–1415/volume:32 Journal of cerebral blood flow and metabolism Journal of Cerebral Blood Flow & Metabolism; Vol 32 Jacobs, A H, Tavitian, B, Lammertsma, A A & Windhorst, A D 2012, ' Noninvasive molecular imaging of neuroinflammation ', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 7, pp. 1393-1415 . https://doi.org/10.1038/jcbfm.2012.53 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1038/jcbfm.2012.53 |
| Popis: | This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License.-- The INMiND consortium: et al. Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and the adaptive immune systems, where resident microglia and infiltrating immune cells from the periphery have important roles. Common diseases of the CNS, such as stroke, multiple sclerosis (MS), and neurodegeneration, elicit a neuroinflammatory response with the goal to limit the extent of the disease and to support repair and regeneration. However, various disease mechanisms lead to neuroinflammation (NI) contributing to the disease process itself. Molecular imaging is the method of choice to try to decipher key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the orchestrated inflammatory response in vivo in animal models and patients. Here, we review the basic principles of NI with emphasis on microglia and common neurologic disease mechanisms, the molecular targets which are being used and explored for imaging, and molecular imaging of NI in frequent neurologic diseases, such as stroke, MS, neurodegeneration, epilepsy, encephalitis, and gliomas. This review is supported in part by DiMI-NoE LSHB-CT-2005-512146, INMiND-LSIP 278850, and IZKF-SchwJ3/001/11. |
| Databáze: | OpenAIRE |
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