Cerebrospinal fluid nitric oxide level changes in preeclampsia
| Autor: | Onder Celik, Remzi Gokdeniz, Mehmet Hascalik, Yusuf Turkoz, Seyma Hascalik |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Population Blood Pressure Gestational Age Nitric Oxide Preeclampsia Nitric oxide chemistry.chemical_compound Cerebrospinal fluid Nitrate Pre-Eclampsia Pregnancy Internal medicine Blood plasma medicine Birth Weight Humans Aspartate Aminotransferases Nitrite education Nitrites education.field_of_study Nitrates business.industry Obstetrics and Gynecology Alanine Transaminase medicine.disease Uric Acid Parity Proteinuria Endocrinology Reproductive Medicine chemistry Female business Perfusion |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 111(2) |
| ISSN: | 0301-2115 |
| Popis: | The purpose of this study was to determine the level of nitric oxide (NO) metabolites, nitrite and nitrate in human cerebrospinal fluid (CSF) and serum and to assess whether there is any relationship among CSF, serum nitrate-nitrite levels and preeclampsia.Twenty-one preeclamptic and 27 healthy pregnant women as control group who underwent cesarean section (C/S) were included in the study. Before administering local anesthetic for spinal anesthesia, 2 ml CSF and 4 ml venous blood sample were taken. CSF and serum total nitrite, direct nitrite and nitrate levels were determined spectrophotometrically.CSF total nitrite, direct nitrite and nitrate levels were significantly different between the two groups (21.00+/-1.68, 8.28+/-0.89 and 12.71+/-1.08 micromol/l, respectively versus 15.53+/-1.49, 5.57+/-0.39 and 9.96+/-1.45 micromol/l, respectively, P0.05). Significantly higher serum nitrate level was found (31.84+/-2.31 micromol/l) in the control group compared to the preeclamptic group serum nitrate level (25.06+/-2.02 micromol/l). Statistical comparisons were performed by the Mann-Whitney U-test.CSF-NO is significantly higher but serum NO is lower in preeclamptic group compared with control group may suggest independent regulation of NO in the two compartments. The determination of CSF-NO metabolites could be useful to clarify whether increased NO production is predominantly associated with poor perfusion of the brain in preeclampsia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect