Assessing the Use of 50% Enantiomeric Excess Bupivacaine-Loaded Microspheres after Sciatic Nerve Block in Rats
| Autor: | Pedro Paulo Tanaka, Rohnelt Machado de Oliveira, Sérgio Bernardo Tenório |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
DOLOR Postoperatoria medicine.drug_class medicine.medical_treatment DOR Pós-Operatória ANIMAL Ratón medicine Animals Anesthetics Local Rats Wistar Enantiomeric excess Bupivacaine Drug Carriers Pain Postoperative ANIMAL Rato Chemistry Local anesthetic ANESTÉSICOS Local bupivacaína Nerve Block Sciatic Nerve Microspheres Rats Blockade Anesthesiology and Pain Medicine Anesthesia Anesthetic Nerve block Sciatic nerve Halothane medicine.drug |
| Zdroj: | Brazilian Journal of Anesthesiology. 61:736-747 |
| ISSN: | 0034-7094 |
| DOI: | 10.1016/s0034-7094(11)70083-6 |
| Popis: | SummaryBackground and objectivesTo achieve better therapeutic benefits of local anesthetics in the control of postoperative pain through controlled-release carrier. The objective of this study was to compare the characteristics of sensory and motor blockade between microspheres without local anesthetic: racemic bupivacaine-loaded microspheres; 50% enantiomeric excess bupivacaine-loaded microspheres; and free 50% enantiomeric excess bupivacaine.MethodsWistar rats were distributed into four groups: A (Microsphere); B (S50–R50 bupivacaine-loaded microsphere); C (50% enantiomeric excess bupivacaine-loaded microsphere); and D (50% enantiomeric excess bupivacaine). Inhalation anesthesia was performed before the sciatic nerve block (2% halothane and 100% O2). Sensorial blockade was measured by the time required for each rat to withdraw its paw from a hot plate at 56°C (positive>4 sec). Motor blockade was measured by the time between drug injection until recovery of a motor score of 2 on the established criterion.ResultsThe sensory response was significantly more frequent in groups B, C, and D than in group A (p0.05). The response to the motor test was also significantly more frequent in groups B, C, and D than in group A (p=0.02). A tendency to greater positivity in the motor test was more frequently found in groups B and D than in group C (p=0.10).ConclusionsControlled-release of 50% enantiomeric excess bupivacaine-loaded microspheres showed similar results regarding analgesia and less motor blockade when compared to other anesthetic formulations. |
| Databáze: | OpenAIRE |
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