The clinical value of serum hepatic parenchyma cell volume-normalized hepatitis B surface antigen levels in hepatitis B e antigen -positive and -negative chronic hepatitis B patients
| Autor: | Zhishuo Mo, Zhiliang Gao, Shi-Lei Xu, Lei Tan, Ze-Qian Wu, Wei-Qiang Gan, Jie-Huan Chen, Jian-Rong Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Hepatitis B virus
HBsAg medicine.medical_specialty medicine.diagnostic_test business.industry virus diseases Inflammation General Medicine medicine.disease_cause medicine.disease Gastroenterology digestive system diseases HBeAg Fibrosis Liver biopsy Internal medicine medicine Original Article medicine.symptom business Hepatic fibrosis Pathological |
| Zdroj: | Ann Transl Med |
| ISSN: | 2305-5847 2305-5839 |
| DOI: | 10.21037/atm-21-3846 |
| Popis: | BACKGROUND: While serum hepatitis B surface antigens (HBsAg) play an important role in the diagnosis and assessment of treatment results of hepatitis B virus (HBV) infections, it remains unclear whether HBsAg levels normalized to hepatic parenchymal cell volume (HPCV) is a superior indicator of disease state. This study compared the absolute and HPCV-normalized serum HBsAg levels in hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients with chronic hepatitis B (CHB). METHODS: Patients admitted to our institution with CHB were retrospectively included and categorized into the HBeAg-positive and HBeAg-negative groups. HPCV was calculated based on pathological examination of liver biopsy specimens and theory of sphere geometry. The difference between HBsAg levels and HBsAg normalized to HPCV, and also correlation between HBsAg levels and liver inflammation and fibrosis was analyzed. RESULTS: Absolute HBsAg levels (P=0.004), but not HPCV-normalized HBsAg levels (P=0.071) were significantly higher in HBeAg-positive patients compared to HBeAg-negative patients. In HBeAg-positive CHB patients, absolute HBsAg levels were positively correlated with liver inflammation grade (R=0.285, P=0.001) and hepatic fibrosis stage (R=0.351, P |
| Databáze: | OpenAIRE |
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