Quantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF Injection: OCT Versus OCT Angiography
| Autor: | Muhammed Altinisik, Ozcan Kayikcioglu, Abdulmutalip Yildirim, Emin Kurt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Visual Acuity Angiogenesis Inhibitors 03 medical and health sciences 0302 clinical medicine Oct angiography Ophthalmology medicine Humans Fluorescein Angiography Retrospective Studies Anti vegf business.industry Infant Newborn Infant General Medicine Optical coherence tomography angiography Choroidal Neovascularization eye diseases Choroidal neovascularization Intravitreal Injections 030221 ophthalmology & optometry Biomarker (medicine) Female sense organs medicine.symptom business Quantitative analysis (chemistry) Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | Seminars in Ophthalmology. 36:573-581 |
| ISSN: | 1744-5205 0882-0538 |
| Popis: | To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection.Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and ~4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT).A total of 27 patients (69.19 ± 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection. |
| Databáze: | OpenAIRE |
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