Fluctuations of plasma beta 2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells
| Autor: | G. Petrillo, D Bulgarini, G. Boccoli, Cesare Peschle, M.G. Sofra, A. Camagna, E. M. Ruggeri, Ugo Testa, E. Montesoro, Rosalba Masciulli, G. Giannella, V. Calzini, Paola Samoggia, G. Mastroberardino, P. Carlini, S. Di Folco, D. Habetswallner, F. Calabresi, M. G. Arena, E Pelosi-Testa |
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| Rok vydání: | 1989 |
| Předmět: |
Interleukin 2
Adoptive cell transfer medicine.medical_treatment Immunology chemical and pharmacologic phenomena Biology Interferon-gamma Immune system Neoplasms medicine Immunology and Allergy Humans Interferon gamma Receptor Lymphokine-activated killer cell Immunization Passive hemic and immune systems Receptors Interleukin-2 Hematology Immunotherapy Recombinant Proteins Killer Cells Natural Cytokine Interleukin-2 beta 2-Microglobulin medicine.drug |
| Zdroj: | Immunobiology. 178(4-5) |
| ISSN: | 0171-2985 |
| Popis: | We report the serum levels of soluble interleukin2 receptor (siL2R), β-microglobulin (β-M) and interferon-γ (IFN-γ) in patients undergoing adoptive immunotherapy with rIL2 and lymphocyte-activated killer (LAK) cells. Our results indicate that rIL 2 induced a marked increase of the serum concentration of these markers, although this increase varied considerably for different individuals. Parallel studies with the same patients also showed a marked rise in the number of IL 2R + lymphocytes: the IL2Rs expressed on these cells were mainly of the «low affinity» type. We suggest that evaluation of these markers may allow the monitoring of immune system activation induced by rIL 2 in patients undergoing adoptive rIL 2 and LAK cell immunotherapy. |
| Databáze: | OpenAIRE |
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