Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation
| Autor: | Marco Virgili, Barbara Monti, Emiliano Peña-Altamira, Federica Prati, Maria Laura Bolognesi, Antonio Contestabile, Francesca Massenzio |
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| Přispěvatelé: | Peña-Altamira, E, Prati, F, Massenzio, F, Virgili, M, Contestabile, A, Bolognesi, Ml, Monti, B. |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.drug_class Clinical Biochemistry Drug target Anti-Inflammatory Agents Inflammation Disease Neuroprotection Anti-inflammatory Immunomodulation 03 medical and health sciences Therapeutic approach 0302 clinical medicine M2 and M1 phenotype Drug Discovery Animals Humans Medicine Amyotrophic lateral sclerosis Pharmacology Microglia business.industry Neurodegenerative Diseases medicine.disease Neurodegenerative diseases 030104 developmental biology medicine.anatomical_structure Molecular Medicine medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Expert Opinion on Therapeutic Targets. 20:627-640 |
| ISSN: | 1744-7631 1472-8222 |
| DOI: | 10.1517/14728222.2016.1121237 |
| Popis: | INTRODUCTION: The importance of microglia in most neurodegenerative pathologies, from Parkinson's disease to amyotrophic lateral sclerosis and Alzheimer's disease, is increasingly recognized. Until few years ago, microglial activation in pathological conditions was considered dangerous to neurons due to its causing inflammation. Today we know that these glial cells also play a crucial physiological and neuroprotective role, which is altered in neurodegenerative conditions. AREAS COVERED: The neuroinflammatory hypothesis for neurodegenerative diseases has led to the trial of anti-inflammatory agents as therapeutics with largely disappointing results. New information about the physiopathological role of microglia has highlighted the importance of immunomodulation as a potential new therapeutic approach. This review summarizes knowledge on microglia as a potential therapeutic target in the most common neurodegenerative diseases, with focus on compounds directed toward the modulation of microglial immune response through specific molecular pathways. EXPERT OPINION: Here we support the innovative concept of targeting microglial cells by modulating their activity, rather than simply trying to counteract their inflammatory neurotoxicity, as a potential therapeutic approach for neurodegenerative diseases. The advantage of this therapeutic approach could be to reduce neuroinflammation and toxicity, while at the same time strengthening intrinsic neuroprotective properties of microglia and promoting neuroregeneration. |
| Databáze: | OpenAIRE |
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