Helicobacter pylori with East Asian-type cag PAI genes is more virulent than strains with Western-type in some cag PAI genes
| Autor: | Xiao-yan Yuan, Jian-li Geng, Yan Hu, Chun-mei Wu, Ya-chao Yang, Jin-Jun Yan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genomic Islands Genotype Virulence Factors lcsh:QR1-502 Virulence Microbiology lcsh:Microbiology Helicobacter Infections 03 medical and health sciences 0302 clinical medicine cagPAI Cluster Analysis Humans CagA Helicobacter Gene Phylogeny Genetics Microscopy Helicobacter pylori IL-8 biology Histocytochemistry Strain (biology) biology.organism_classification Pathogenicity island 030104 developmental biology Gastric Mucosa Medical Microbiology 030220 oncology & carcinogenesis |
| Zdroj: | Brazilian Journal of Microbiology Brazilian Journal of Microbiology v.48 n.2 2017 Sociedade Brasileira de Microbiologia (SBM) instacron:SBM Brazilian Journal of Microbiology, Volume: 48, Issue: 2, Pages: 218-224, Published: JUN 2017 Brazilian Journal of Microbiology, Vol 48, Iss 2, Pp 218-224 |
| ISSN: | 1517-8382 |
| DOI: | 10.1016/j.bjm.2016.12.004 |
| Popis: | The severity of Helicobacter pylori-related disease is correlated with the presence and integrity of a cag pathogenicity island (cagPAI). cagPAI genotype may have a modifying effect on the pathogenic potential of the infecting strain. After analyzing the sequences of cagPAI genes, some strains with the East Asian-type cagPAI genes were selected for further analysis to examine the association between the diversity of the cagPAI genes and the virulence of H. pylori. The results showed that gastric mucosal inflammatory cell infiltration was significantly higher in patients with East Asian-type cagPAI genes H. pylori strain compared with mosaicism cagPAI genes H. pylori strain (p < 0.05). H. pylori strains with the East Asian-type cagPAI genes were closely associated with IL-8 secretion in vitro and in vivo compared with H. pylori strains with the mosaicism cagPAI genes (p < 0.01). H. pylori strains with East Asian-type cagPAI genes are able to strongly translocate CagA to host cells. These results suggest that H. pylori strains with East Asian-type cagPAI genes are more virulent than the strains of cagPAI gene/genes that are Western type. |
| Databáze: | OpenAIRE |
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