Immune complex induced experimental colitis: beneficial effect of sulphasalazine in rabbits
| Autor: | L.-G. Axelsson, S. Ahlstedt |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Crypt Inflammation Cross Reactions Gastroenterology Antibodies Immune system Antigen Internal medicine Escherichia coli Animals Immune Complex Diseases Medicine Pharmacology (medical) Intestinal Mucosa Colitis Hepatology business.industry Serum Albumin Bovine medicine.disease Antibodies Bacterial Intestinal epithelium Immune complex Sulfasalazine Immunology Female Rabbits medicine.symptom business Crypt Abscess |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 4:255-263 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.1990.tb00470.x |
| Popis: | SUMMARY Experimental colitis was induced in rabbits by exposing the colon mucosa to 1% formalin followed by i.v. injections of soluble immune complexes made with antigen in excess. The animals were preimmunized with Esherichia coli 014:K7:H — inducing antibodies cross-reactive to intestinal epithelium. Animals with this colitis were divided in two groups. One group was treated with sulphasalazine and the other was given vehicle only. Sulphasalazine was administered daily at 125.5 μmol (50 mg) per kg body weight. The administration was started at the same day as the colitis was initiated. At Day 6, 13 and 30 following induction of colitis, biopsies were sampled and histologically evaluated. Inflammation was assessed by scores for inflammatory cells, crypt distortion, decreased crypt number and presence of crypt abscesses, thus corresponding to the picture seen in humans. A statistically significant lower score of inflammation was seen on Day 6 and 13 (P < 0.01) and on Day 30 (P < 0.05) following induction of colitis in animals treated with sulphasalazine. |
| Databáze: | OpenAIRE |
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