Increased CCR4 expression in active systemic lupus erythematosus
| Autor: | Yasukazu Ohmoto, Kayoko Hase, Teruki Shimizu, Kenji Tani, Kouji Matsushima, Saburo Sone |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Receptors CCR4 Adolescent Immunology CCR4 Biology Severity of Illness Index Autoimmune Diseases Immune system Th2 Cells Blisibimod medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Lupus erythematosus Antibodies Monoclonal Cell Biology Middle Aged medicine.disease Flow Cytometry Interleukin-10 Interleukin 10 Gene Expression Regulation Antibodies Antinuclear biology.protein Prednisone Female Receptors Chemokine Interleukin-4 Antibody CC chemokine receptors Immunosuppressive Agents Anti-SSA/Ro autoantibodies |
| Zdroj: | Journal of leukocyte biology. 70(5) |
| ISSN: | 0741-5400 |
| Popis: | CC chemokine receptor (CCR)4 is selectively expressed on Th2-type Tcells and has been shown to be responsible for Th2-dominant immuneresponses. In this study, we analyzed the expression of CCR4 in activesystemic lupus erythematosus (SLE) patients by FACS analysis usinganti-human CCR4 monoclonal antibody and determined the clinicalrelevance in this disease. Higher expression of CCR4 was found onperipheral blood CD4+ T lymphocytes of active SLE patients than wasfound with healthy controls and inactive SLE patients. The CCR4expression significantly correlated with the SLE disease activity index(SLEDAI) scores. The expression was dramatically decreased after thecorticosteroid therapy in parallel with a serum level ofdouble-stranded DNA antibody and SLEDAI scores. Moreover, we found thatserum levels of IL-10 were increased in active SLE patients andsignificantly correlated with the CCR4 expression. This study suggeststhat Th2 immune response is predominant in the active state of SLE, andCCR4 may have relevance in regard to the disease course in SLEpatients. |
| Databáze: | OpenAIRE |
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