Effect of Papain-Induced Emphysema on Permeability of Rat Lung to Drugs
| Autor: | Thomas H. Gardiner, Lewis S. Schanker |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Drug
Absorption (pharmacology) media_common.quotation_subject Procainamide Pharmacology Permeability General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Pulmonary Absorption Papain medicine Animals Mannitol Lung media_common Aerosols Aminohippuric Acids Organ Size respiratory system Cannula Rats medicine.anatomical_structure Pulmonary Emphysema chemistry Distilled water medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 149:972-977 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-149-38937 |
| Popis: | SummaryTo investigate the effect of a papain-induced emphysema-like condition on pulmonary absorption of drugs, rats were exposed to either papain aerosol or distilled water aerosol (control) intermittently for 2 wk, and rates of drug absorption from damaged and control lungs were compared. To measure absorption rates, 0.1 ml of drug solution (0.1-10 mM) was administered through a tracheal cannula to anesthetized animals, and after various times lungs were assayed for unabsorbed compound. In absorption experiments with the lipoid-insoluble compounds, mannitol, p-aminohippuric acid, and procaine amide ethobromide, all three drugs were absorbed from the lungs about twice as rapidly in papain-treated rats as in control. In contrast, procaine amide, a relatively lipoid-soluble drug, was absorbed at the same rate in both control and papain-treated animals. The results suggest that papain-induced lung damage increases the porosity of the pulmonary epithelium.The authors are indebted to Mrs. Jean C. Henderson fo... |
| Databáze: | OpenAIRE |
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