Zika Virus Activity of the Leaf and Branch Extracts of Tontelea micrantha and Its Hexane Extracts Phytochemical Study
| Autor: | Louise S. M. da Silva, José Carlos de Magalhães, Marcela S. Hauck, Maria Olívia Mercadante-Simões, Júlio César Dias Lopes, Fernanda L. Ferreira, Lúcia Pinheiro Santos Pimenta, Sidney Augusto Vieira Filho, Lucienir Pains Duarte |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Ethyl acetate 010501 environmental sciences 01 natural sciences 21-trione Zika virus Celastraceae Squalene chemistry.chemical_compound Triterpene Fourier transform infrared spectroscopy 0105 earth and related environmental sciences chemistry.chemical_classification friedelan-1 3 Chromatography biology Tontelea micrantha General Chemistry biology.organism_classification 010601 ecology Hexane chemistry Phytochemical antiviral activity Gas chromatography |
| Zdroj: | Journal of the Brazilian Chemical Society, Volume: 30, Issue: 4, Pages: 793-803, Published: APR 2019 Journal of the Brazilian Chemical Society v.30 n.4 2019 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| Popis: | The new triterpene friedelan-1,3,21-trione, the known compounds friedelan-3-one, 3β-friedelinol, 3,4-seco-friedelan-3-oic acid, 28-hydroxyfriedelan-3-one, friedelan-3-oxo-28-al, friedelan-3,21-dione, 30-hydroxyfriedelan-3-one, a mixture of 30-hydroxyfriedelan-3-one/21α-hydroxyfriedelan-3-one, 21β-hydroxyfriedelan-3-one, gutta-percha, squalene, and a mixture of palmitic/stearic/oleic acids were isolated from the hexane extracts of leaves and branches of T. micrantha. Their chemical structures were established by Fourier transform infrared spectroscopy (FTIR), gas chromatography (GC), 1D/2D nuclear magnetic resonance (NMR) and comparison with the literature data. All compounds were described for T. micrantha and the genus Tontelea for the first time. The branch and leaf extracts displayed anti-Zika virus activity at the lowest tested concentration of 15.6 µg mL-1, mainly virucidal effect, and presented no cytotoxicity to Vero cells. Furthermore, the ethyl acetate and methanolic leaf extracts demonstrated the best activities at the concentration of 31.2 and 15.6 µg mL-1 at the viral adsorption and penetration stages, respectively. These results showed that these extracts may be promising candidates for the Zika virus treatment. |
| Databáze: | OpenAIRE |
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