Impaired glucose homeostasis in non-diabetic Greek hypertensives with diabetes family history. Effect of the obesity status
| Autor: | Gregory P. Vyssoulis, Charalampos I. Liakos, Christodoulos Stefanadis, Maria I. Markou, Eva A. Karpanou, Vanessa Tzamou, Andreas P. Michaelides, Athanasios I. Triantafyllou |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Type 2 diabetes Prediabetic State Impaired glucose tolerance chemistry.chemical_compound Insulin resistance Risk Factors Internal medicine Glucose Intolerance Prevalence Internal Medicine medicine Homeostasis Humans Glucose homeostasis Obesity Aged Family Health Metabolic Syndrome Greece business.industry Quantitative insulin sensitivity check index Middle Aged medicine.disease Impaired fasting glucose Endocrinology Glycemic index Diabetes Mellitus Type 2 chemistry Glycemic Index Hypertension Female Glycated hemoglobin Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of the American Society of Hypertension. 7:294-304 |
| ISSN: | 1933-1711 |
| DOI: | 10.1016/j.jash.2013.02.007 |
| Popis: | Arterial hypertension (AH) and diabetes mellitus (DM) are established cardiovascular risk factors. Impaired glucose homeostasis (IGH; impaired fasting glucose or/and impaired glucose tolerance) or pre-diabetes, obesity, and DM family history identify individuals at risk for type 2 DM in whom preventive interventions are necessary. The aim of this study was to determine the glycemic profile in non-diabetic Greek adult hypertensive men and women according to DM family history and the obesity status. Diabetes family history, obesity markers (waist-to-hip ratio, WHR; body mass index, BMI), glycemic parameters (fasting and 2-hour post-load plasma glucose, if necessary; glycated hemoglobin, HbA1c; fasting insulin), insulin resistance indices (homeostasis model assessment, HOMA; quantitative insulin sensitivity check index, QUICKI; Bennett; McAuley), and IGH prevalence were determined in a large cohort of 11,540 Greek hypertensives referred to our institutions. Positive DM family history was associated with elevated fasting glucose (98.6 ± 13.1 vs 96.5 ± 12.3 mg/dL), HbA1c (5.58% ± 0.49% vs 5.50% ± 0.46%), fasting insulin (9.74 ± 4.20 vs 9.21 ± 3.63 μU/mL) and HOMA (2.43 ± 1.19 vs 2.24 ± 1.01) values, lower QUICKI (0.342 ± 0.025 vs 0.345 ± 0.023), Bennett (0.285 ± 0.081 vs 0.292 ± 0.078) and McAuley (6.73 ± 3.43 vs 6.95 ± 3.44) values, and higher IGH prevalence (45.3% vs 38.7%); P.01 for all comparisons. The difference in the prevalence of IGH according to DM family history was significant (P.01) in both genders and every WHR and BMI subgroup (except for women with BMI20 kg/m(2)). Non-diabetic hypertensives with positive DM family history present with higher IGH prevalence and worse glycemic indices levels compared with those with negative family history, especially in the higher WHR/BMI subgroups. |
| Databáze: | OpenAIRE |
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