Allergy to Polyethilenglicole of Anti-SARS CoV2 Vaccine Recipient: A Case Report of Young Adult Recipient and the Management of Future Exposure to SARS-CoV2
| Autor: | Ignazio Brusca, Rosa Onida, Maurizio Raineri, Vincenzo Restivo, Maria Barrale, Salvatore Tiralongo, Ester Caravello, Giuseppina Candore, Giorgio Graziano |
|---|---|
| Přispěvatelé: | Restivo V., Candore G., Barrale M., Caravello E., Graziano G., Onida R., Raineri M., Tiralongo S., Brusca I. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Allergy Immunology adverse reaction Case Report Vial 03 medical and health sciences 0302 clinical medicine Internal medicine vaccine Drug Discovery medicine anaphylaxis Pharmacology (medical) 030212 general & internal medicine Adverse effect Contraindication Dexamethasone Pharmacology m-RNA vaccine business.industry SARS CoV2 medicine.disease PEG Adverse reaction Anaphylaxis Basophil activation test Contraindica-tion M-RNA vaccine PEG SARS CoV2 Vaccine Vaccination Infectious Diseases 030228 respiratory system basophil activation test Medicine business Anaphylaxis Adverse drug reaction contraindication medicine.drug |
| Zdroj: | Vaccines, Vol 9, Iss 412, p 412 (2021) Vaccines |
| Popis: | The main contraindication to the anti-SARS CoV2 vaccine is an anaphylactic reaction to a vaccine component. The need to vaccinate allergic people who are at higher risk can be of public health interest and this report shows a case of an allergic reaction to PEG of a HCW who had received the first dose of anti-SARS CoV2 vaccine. For 5 h after the administration of the vaccine, she had the appearance of erythematous spots on the face and neck, and a feeling of a slurred mouth and hoarseness. In order to treat the event, she was administered 8 mg intravenous dexamethasone, 1 vial intravenous chlorphenamine maleate, 250 mL intravenous 0.9% NaCl, and conventional oxygen therapy (2 L/min) with complete resolution of the suspected adverse drug reaction. According to the contraindication to the cutaneous test for this patient, BAT was used for further investigations. The patient who suffered the adverse reaction to the COVID-19 vaccine and other five allergic patients who did not report any adverse reaction after the vaccination were tested. There was a significant activation of the vaccine-reactive patient’s basophils with 14.79 CD203chigh% at the concentration of 0.2 mg/mL, while other patients were negative. People who have a confirmed reaction to a vaccine component should undergo further investigation to discover other possible cross-reactions and select the right vaccine to immunize them. |
| Databáze: | OpenAIRE |
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