Abnormal cortical activation during silent reading in adolescents with autism spectrum disorder
| Autor: | Ikuko Mohri, Masayuki Hirata, Rei Ogawa, Koji Tominaga, Ryuzo Hanaie, Kuriko Kagitani-Shimono, Tomoka Yamamoto, Masako Taniike, Junpei Tanigawa, Junko Matsuzaki |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent genetic structures Autism Spectrum Disorder Temporoparietal junction Neuropsychological Tests Audiology behavioral disciplines and activities Functional Laterality Lateralization of brain function 03 medical and health sciences Superior temporal gyrus Imaging Three-Dimensional 0302 clinical medicine Developmental Neuroscience mental disorders medicine Humans Language Cerebral Cortex Brain Mapping Fusiform gyrus medicine.diagnostic_test Magnetoencephalography General Medicine medicine.disease Magnetic Resonance Imaging Developmental disorder medicine.anatomical_structure Reading Autism spectrum disorder Communication Disorders Pediatrics Perinatology and Child Health Neurology (clinical) Psychology Insula 030217 neurology & neurosurgery |
| Zdroj: | Brain and Development. 41:234-244 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/j.braindev.2018.10.013 |
| Popis: | Objective Autism spectrum disorder (ASD) is a developmental disorder characterized by communication deficits and social difficulties, and individuals with ASD frequently exhibit varied levels of language abilities. However, the neurophysiological mechanisms underlying their language deficits remain unclear. To gain insight into the neurophysiological mechanisms of receptive language deficits, we assessed cortical activation patterns in adolescents with ASD during silent word-reading. Methods We used magnetoencephalography to measure cortical activation during a silent word-reading task in 14 adolescent boys with high-functioning ASD and 17 adolescent boys with typical development (TD). Results Compared with participants with TD, those with ASD exhibited significantly decreased cortical activation in the left middle temporal gyrus, left temporoparietal junction, bilateral superior temporal gyrus, left posterior insula, and right occipitotemporal gyrus, and increased activation in the right anterior insula. Participants with ASD also exhibited a lack of left-lateralization in the central sulcus and abnormal right-lateralization in the anterior insula area. Furthermore, in participants with ASD, we found that abnormal activation of the right central sulcus correlated significantly with lower visual word comprehension scores, and that decreased activation of the right anterior insula correlated significantly with the severity of social interaction difficulties. Conclusion Our findings suggest that atypical cortical activation and lateralization in the temporal-frontal area, which is associated with higher-order language processing functions, such as semantic analysis, may play a crucial role in visual word comprehension and social interaction difficulties in adolescents with ASD. |
| Databáze: | OpenAIRE |
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