Intracarotid VP-16 in malignant brain tumors
| Autor: | Wai Kwan Alfred Yung, Lynn G. Feun, ya Yen Lee, Sidney Wallace, Niramol Savaraj |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Neurology Adolescent medicine.medical_treatment Astrocytoma Route of administration Glioma medicine Humans Infusions Intra-Arterial Primary Brain Tumors Child Etoposide Aged Chemotherapy business.industry Brain Neoplasms Middle Aged medicine.disease Oncology Tumor progression Female Neurology (clinical) business Carotid Artery Internal medicine.drug |
| Zdroj: | Journal of neuro-oncology. 4(4) |
| ISSN: | 0167-594X |
| Popis: | Twenty-eight patients with malignant brain tumors (16 with primary brain tumors and 12 with brain metastases) progressing after cranial irradiation with or without chemotherapy received varying doses of intracarotid VP-16. Courses of therapy were repeated every 4 weeks along with computerized axial tomography scan and neurologic examination. Of 15 evaluable patients with primary malignant brain tumors, 1 responded to therapy and 5 had no immediate tumor progression for 2-10 months. None of 12 evaluable patients with brain metastases responded to intracarotid VP-16 although 5 had no immediate tumor progression from 1-4 months. Side effects of treatment were uncommon. Using this route of administration, intracarotid VP-16 does not appear to increase response rates in patients with primary malignant brain tumors, compared with results reported for intravenous VP-16. |
| Databáze: | OpenAIRE |
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