Allogeneic transplantation across major HLA barriers
| Autor: | P. Jean Henslee-Downey |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Allogeneic transplantation business.industry Histocompatibility Testing Clinical Biochemistry Graft vs Host Disease Human leukocyte antigen Histocompatibility Transplantation surgical procedures operative medicine.anatomical_structure Haplotypes Oncology Cord blood Internal medicine Immunopathology Immunology medicine Humans Transplantation Homologous Bone marrow business Stem Cell Transplantation |
| Zdroj: | Best Practice & Research Clinical Haematology. 14:741-754 |
| ISSN: | 1521-6926 |
| Popis: | Only one-fourth of patients with fatal haematological disorders and malignancies will have an HLA-matched sibling donor to create access to potentially curative allogeneic stem cell transplantation. Advances in medical management, preparation of the graft and prevention of transplant-related complications, particularly rejection and GVHD, now make it possible to use alternative donors who are not genetically HLA-histocompatible with the patient. Some patients identify unrelated donor options using adult volunteers or cord blood units. All patients have immediate access to one or more genetically half-matched (haplo-identical), HLA partially-mismatched related donors. Using safer non-cytotoxic therapies to ablate the patient's immune system, graft preparation to decrease T-lymphocyte and/or increase CD 34+ cell doses, and post-transplant GVHD and infection prophylaxis, rates >95% for engraftment and |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect