Preliminary report of associated factors in wound infection after major head and neck neoplasm operations--does the duration of prophylactic antibiotic matter?
| Autor: | Chiu Yt, Tung Kc, Liu Sa, Shiao Jy |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics Cefazolin Free flap Drug Administration Schedule Surgical Flaps Hemoglobins Double-Blind Method medicine Humans Surgical Wound Infection Prospective Studies Prospective cohort study Aged Neoplasm Staging business.industry Clindamycin Surgical wound General Medicine Odds ratio Antibiotic Prophylaxis Middle Aged Confidence interval Surgery Anti-Bacterial Agents Otorhinolaryngology Head and Neck Neoplasms Female business medicine.drug |
| Zdroj: | The Journal of laryngology and otology. 122(4) |
| ISSN: | 1748-5460 |
| Popis: | The aim of this study was to investigate whether an extended course of prophylactic antibiotic could reduce the wound infection rate in a subtropical country. Fifty-three consecutive cases scheduled to receive major head and neck operations were randomised into one-day or three-day prophylactic antibiotic groups. Thirteen cases (24.5 per cent) developed wound infections after operations. The duration of prophylactic antibiotic was not related to the surgical wound infection. However, pre-operative haemoglobulin less than 10.5 g/dl (odds ratio: 7.24, 95 per cent confidence interval: 1.28–41.0) and reconstruction with a free flap or pectoris major myocutaneous flap during the operation (odds ratio: 11.04, 95 per cent confidence interval: 1.17–104.7) were associated factors significantly influencing post-operative wound infection. Therefore, one day of prophylactic antibiotic was effective in major head and neck procedures but should not be substituted for proper aseptic and meticulous surgical techniques. |
| Databáze: | OpenAIRE |
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