A review of Vicieae lectins studies: End of the book or a story in the writing?
| Autor: | Benildo Sousa Cavada, Kyria S. Nascimento, Vinicius Jose Da Silva Osterne, Messias Vital Oliveira, Claudia Figueiredo Lossio, Vanir Reis Pinto-Junior |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Mitogenic lectin biology Vicia Agglutination Carbohydrates Single gene 02 engineering and technology General Medicine Fabaceae 021001 nanoscience & nanotechnology biology.organism_classification Biochemistry 03 medical and health sciences Structural Biology Lectins Lens culinaris lectin Amino Acid Sequence Vavilovia 0210 nano-technology Molecular Biology 030304 developmental biology |
| Zdroj: | International Journal of Biological Macromolecules. 181:1104-1123 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2021.04.062 |
| Popis: | Vicieae tribe, Leguminosae family (Fabaceae), has been extensively studied. In particular, the study of lectins. The purification, physicochemical and structural characterizations of the various purified lectins and the analysis of their relevant biological activities are ongoing. In this review, several works already published about Vicieae lectins are addressed. Initially, we presented the purification protocols and the physicochemical aspects, such as specificity for carbohydrates, optimal activity in the face of variations in temperature and pH, as well metals-dependence. Following, structural characterization studies are highlighted and, finally, various biological activities already reported are summarized. Studies on lectins in almost all genera (Lathyrus, Lens, Pisum and Vicia) are considered, with the exception of Vavilovia which studies of lectins have not yet been reported. Like other leguminous lectins, Vicieae lectins present heterogeneous profiles of agglutination profiles for erythrocytes and other cells of the immune system, and glycoproteins. Most Vicieae lectins consist of two subunits, α and β, products of a single precursor protein derived from a single gene. The differences between the isoforms result from varying degrees of proteolytic processing. Along with the identification of these molecules and their characteristics, biological activities become very relevant and robust for both basic and applied research. |
| Databáze: | OpenAIRE |
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