Dietary fatty acids alter blood pressure, behavior and brain membrane composition of hypertensive rats

Autor: de Wilde, MC, Hogyes, E, Kiliaan, AJ, Farkas, T, Luiten, PGM, Farkas, E, Wilde, Martijn C. de, Hőgyes, Endre, Kiliaan, Amanda J.
Přispěvatelé: Van der Zee lab
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Male
STRESS
Hemodynamics
Blood lipids
Blood Pressure
Rats
Inbred WKY
Lipid peroxidation
chemistry.chemical_compound
Cognition
Rats
Inbred SHR
chronic hypertension
Phospholipids
Hypolipidemic Agents
Cerebral Cortex
Neurons
chemistry.chemical_classification
Behavior
Animal
General Neuroscience
spatial learning
Brain
food and beverages
polyunsaturated fatty acid
OIL
LIPID-PEROXIDATION
LEARNING-ABILITY
Docosahexaenoic acid
Hypertension
Saturated fatty acid
Fatty Acids
Unsaturated
SERUM-LIPIDS
lipids (amino acids
peptides
and proteins)
Polyunsaturated fatty acid
medicine.medical_specialty
Chromatography
Gas
PHASE
Biology
Cognitive neurosciences [UMCN 3.2]
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Learning
Molecular Biology
Triglycerides
Body Weight
Cell Membrane
Fatty acid
neuronal membranes
IN-VITRO
DOCOSAHEXAENOIC ACID
BARRIER
Dietary Fats
Rats
Blood pressure
Endocrinology
chemistry
Space Perception
Neurology (clinical)
CEREBRAL HYPOPERFUSION
Developmental Biology
Zdroj: Brain-research, 988(1-2), 9-19. ELSEVIER SCIENCE BV
Brain Research, 988, 1-2, pp. 9-19
Brain Research, 988, 9-19
ISSN: 0006-8993
DOI: 10.1016/s0006-8993(03)03320-1
Popis: The beneficial effect of dietary n-3 polyunsaturated fatty acids (PUFAs) on developing hypertension has been repeatedly demonstrated. However. related changes in brain membrane composition and its cognitive correlates have remained unclear. Our study aimed at a comprehensive analysis of behavior and cerebral fatty acid concentration in hypertension after long-term PUFA-rich dietary treatment. Hypertensive and normotensive rats were provided a placebo, or one of two PUFA-enriched diets with a reduced (n-6)/(n-3) ratio for 75 weeks. Exploratory behavior and spatial learning capacity were tested. Systolic blood pressure (BP) was repeatedly measured. Finally, brain fatty acid composition was analyzed by gas chromatography. Hypertensive rats exhibited more active exploration but impaired spatial learning compared to normotensives. Both diets reduced BP, increased PUFA and monounsaturated fatty acid (MUFA) concentration, and reduced saturated fatty acid content in brain. The level of cerebral PUFAs and MUFAs was lower in hypertensive than in normotensive rats. Furthermore, BP positively, while spatial learning negatively correlated with cerebral (n-6)/(n-3) PUFA ratio. We concluded that regular n-3 PUFA consumption could prevent the development of hypertension, but reached only a very delicate improvement in spatial learning. Furthermore. we consider a potential role of metabolically generated MUFAs in the beneficial effects of PUFA supplementation. (C) 2003 Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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