Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in South America
| Autor: | Gladys Velázquez Aguayo, Tayita Ugarte Cuba, Juana Ortellado-Canese, Tamara Nuñez Quezada, Nadya Bastyas, Norah Balderrama Yarhui, Glenda Castro Cañarte, Raquel Magne Ventura, Cecilia Pandolfo, Angela Famiglietti, Natalia Valenzuela, María Inés Mota, Carlos Hernán Rodríguez, Marcela Nastro, Freddy Roach, Noelia Burger, Geni Bruni |
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| Rok vydání: | 2016 |
| Předmět: |
Acinetobacter baumannii
0301 basic medicine Microbiology (medical) Genotype 030106 microbiology Population Polymerase Chain Reaction Microbiology beta-Lactam Resistance beta-Lactamases law.invention 03 medical and health sciences Bacterial Proteins law Humans Typing education Polymerase chain reaction Sequence (medicine) Molecular Epidemiology education.field_of_study Molecular epidemiology biology General Medicine South America biology.organism_classification Hospitals Anti-Bacterial Agents Carbapenems Multilocus sequence typing Acinetobacter Infections Multilocus Sequence Typing |
| Zdroj: | Journal of Medical Microbiology. 65:1088-1091 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.000328 |
| Popis: | One hundred and twenty-six epidemiologically sequential, unrelated, carbapenem-resistant Acinetobacter baumannii isolates from nine hospitals in six countries of South America were collected between July 2013 and June 2014. Genes coding for Ambler class D and B carbapenemases were sought by PCR. All isolates were typed using the 3-locus sequence typing and blaOXA-51-like sequence-based typing techniques. The blaOXA-23 gene was recovered in all the participating hospitals and in all the isolates of seven of nine medical centres. The blaOXA-72 gene was only recovered in the two medical centres from Guayaquil city, Ecuador. Trilocus sequence typing revealed the presence of sequence groups SG2, SG4 and SG5. blaOXA-51-like sequence-based typing revealed the presence of blaOXA-132, blaOXA-65, blaOXA-69 and blaOXA-64. Our results showed that the population of carbapenem-resistant A. baumannii in South America was principally associated with ST79, ST25 and ST15 (92 %) and harboured the blaOXA-23 gene mainly. CC2 was not detected. |
| Databáze: | OpenAIRE |
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