Longitudinal ultrasonic dimensions and parametric solid models of the gravid uterus and cervix

Autor: Erin Marie Louwagie, Helen Feltovich, Veronica Helen Marquez Over, Shuyang Fang, Lu Mao, Joy Vink, Kristin M. Myers, Timothy C. Hall, Lindsey C. Carlson, Andrea R. Westervelt
Rok vydání: 2021
Předmět:
Maternal Health
Uterus
Cervix Uteri
Cervix
Diagnostic Radiology
Labor and Delivery
Pregnancy
Ultrasound Imaging
Medicine and Health Sciences
Biomechanics
Longitudinal Studies
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Ultrasound
Obstetrics and Gynecology
Gestational age
Magnetic Resonance Imaging
medicine.anatomical_structure
Parametric model
Medicine
Female
Anatomy
Genital Anatomy
Research Article
Adult
Imaging Techniques
Science
Gestational Age
Solid modeling
Research and Analysis Methods
Preterm Birth
Models
Biological
Ultrasonography
Prenatal
Imaging
Three-Dimensional
Diagnostic Medicine
medicine
Humans
business.industry
Reproductive System
Biology and Life Sciences
Magnetic resonance imaging
medicine.disease
Pregnancy Complications
Birth
Women's Health
business
Biomedical engineering
Zdroj: PLoS ONE, Vol 16, Iss 1, p e0242118 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Tissue mechanics is central to pregnancy, during which maternal anatomic structures undergo continuous remodeling to serve a dual function to first protect the fetus in utero while it develops and then facilitate its passage out. In this study of normal pregnancy using biomechanical solid modeling, we used standard clinical ultrasound images to obtain measurements of structural dimensions of the gravid uterus and cervix throughout gestation. 2-dimensional ultrasound images were acquired from the uterus and cervix in 30 pregnant subjects in supine and standing positions at four time points during pregnancy (8-14, 14-16, 22-24, and 32-34 weeks). Offline, three observers independently measured from the images of multiple anatomic regions. Statistical analysis was performed to evaluate inter-observer variance, as well as effect of gestational age, gravity, and parity on maternal geometry. A parametric solid model developed in the Solidworks computer aided design (CAD) software was used to convert ultrasonic measurements to a 3-dimensional solid computer model, from which estimates of uterine and cervical volumes were made. This parametric model was compared against previous 3-dimensional solid models derived from magnetic resonance frequency images in pregnancy. In brief, we found several anatomic measurements easily derived from standard clinical imaging are reproducible and reliable, and provide sufficient information to allow biomechanical solid modeling. This structural dataset is the first, to our knowledge, to provide key variables to enable future computational calculations of tissue stress and stretch in pregnancy, making it possible to characterize the biomechanical milieu of normal pregnancy. This vital dataset will be the foundation to understand how the uterus and cervix malfunction in pregnancy leading to adverse perinatal outcomes.
Databáze: OpenAIRE
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