T cell regeneration after allogeneic and autologous bone marrow transplantation
| Autor: | E. G. Davis, Ah Goldstone, R.M. Thomas, L. J. Knott, Pg Harper, R.J. Levinski, D. C. Linch |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Adolescent medicine.drug_class T-Lymphocytes T cell Graft vs Host Disease Monoclonal antibody T-Lymphocytes Regulatory Transplantation Autologous law.invention Leukocyte Count Antigen law Humans Transplantation Homologous Medicine Child Aged Bone Marrow Transplantation Leukemia business.industry Regeneration (biology) Histocompatibility Antigens Class II Immunologic Deficiency Syndromes Antibodies Monoclonal Infant HLA-DR Antigens T-Lymphocytes Helper-Inducer Venous blood Hematology Middle Aged Phenotype Thymocyte surgical procedures operative medicine.anatomical_structure Child Preschool Immunology Suppressor business |
| Zdroj: | British Journal of Haematology. 53:451-458 |
| ISSN: | 0007-1048 |
| Popis: | Summary. Venous blood T cell phenotypes were analysed with monoclonal antibodies after 11 allogeneic and 17 autologous bone marrow transplants. In seven cases studied in the early regenerative period, cells with a thymocyte phenotype were present in the blood. In the large majority of patients treated with both allografts and autografts there was an imbalance of phenotypic ‘helper’ and ‘suppressor’ T cell subsets with initially a relative and later an absolute increase of ‘suppressor’ T cells. This imbalance was still present at over 250 d in eight out nine cases. Suppressor T cells bearing HLA-Dr antigens were abundant in one case of fatal GVHD but not in another, and were also increased following two autografts. It is concluded that T cell phenotyping is not of diagnostic value in sick patients following bone marrow transplantation when graft-versus-host disease is suspected. |
| Databáze: | OpenAIRE |
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