One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation
| Autor: | Louis C. Morrill, Daniel E. Latham, Jonathan M. J. Williams, Kurt Polidano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Allylic rearrangement
Letter 010405 organic chemistry Chemistry Iron catalyzed organic chemicals Organic Chemistry food and beverages Methylation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Cyclopentadienone Yield (chemistry) Methanol Physical and Theoretical Chemistry Isomerization |
| Zdroj: | Organic Letters |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization–methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization–methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield). |
| Databáze: | OpenAIRE |
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