Molecular fingerprint of precancerous lesions in breast atypical hyperplasia
| Autor: | Zhong Bing Ma, De Zong Gao, Jian Guo Zhang, Hong Chuan Jiang, Yu Juan Xiang, Liang Li, Li Yuan Liu, Chao Zheng, Feng Jin, Zhi Min Fan, Shu Wang, Xiang Wang, Fei Wang, Shu Ya Huang, Li Li Tang, Fernandez-Escobar Alejandro, Fei Zhou, Li Xiang Yu, Qiang Zhang, Li Song Teng, Hong Ying Jia, Cui Zhi Geng, Qin Ye Fu, Zhigang Yu, Qi Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Medicine (General) China Prospective Clinical Research Report Breast Neoplasms Breast atypical hyperplasia Molecular Fingerprint Biochemistry Atypical hyperplasia 03 medical and health sciences 0302 clinical medicine Breast cancer R5-920 medicine Humans Breast skin and connective tissue diseases Hyperplasia business.industry Biochemistry (medical) shell-isolated nanoparticle Cell Biology General Medicine molecular fingerprint medicine.disease atypical hyperplasia 030104 developmental biology 030220 oncology & carcinogenesis Raman spectroscopy Female Molecular Fingerprinting business Precancerous Conditions early diagnosis |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 48 (2020) |
| ISSN: | 1473-2300 |
| Popis: | Objective To identify atypical hyperplasia (AH) of the breast by shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS), and to explore the molecular fingerprinting characteristics of breast AH. Methods Breast hyperplasia was studied in 11 hospitals across China from January 2015 to December 2016. All patients completed questionnaires on women’s health. The differences between patients with and without breast AH were compared. AH breast lesions were detected by Raman spectroscopy followed by the SHINERS technique. Results There were no significant differences in clinical features and risk-related factors between patients with breast AH (n = 37) and the control group (n = 2576). Fifteen cases of breast AH lesions were detected by Raman spectroscopy. The main different Raman peaks in patients with AH appeared at 880, 1001, 1086, 1156, 1260, and 1610 cm−1, attributed to the different vibrational modes of nucleic acids, β-carotene, and proteins. Shell-isolated nanoparticles had different enhancement effects on the nucleic acid, protein, and lipid components in AH. Conclusion Raman spectroscopy can detect characteristic molecular changes in breast AH lesions, and may thus be useful for the non-invasive early diagnosis and for investigating the mechanism of tumorigenesis in patients with breast AH. |
| Databáze: | OpenAIRE |
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