Disorganization of Retinal Inner Layers (DRIL) and Neuroretinal Dysfunction in Early Diabetic Retinopathy
| Autor: | Chris A. Johnson, Vinicius M. de Castro, Katherine A. Joltikov, Christopher Sesi, Neil Farbman, Rohit Anand, Thomas W. Gardner, Sami M. Khan, Gregory R. Jackson, Jose R. Davila |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Visual acuity media_common.quotation_subject Vision Disorders Visual Acuity DRIL Pilot Projects Macular Edema Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine perimetry Ophthalmology Diabetes mellitus medicine Contrast (vision) Humans Retinal thinning media_common Aged 2. Zero hunger contrast sensitivity Diabetic Retinopathy medicine.diagnostic_test business.industry Fundus photography Retinal Diabetic retinopathy Middle Aged medicine.disease 3. Good health 030104 developmental biology chemistry Diabetes Mellitus Type 2 OCT 030221 ophthalmology & optometry Biomarker (medicine) Visual Field Tests Female medicine.symptom Visual Fields business Tomography Optical Coherence |
| Zdroj: | Investigative Ophthalmology & Visual Science |
| ISSN: | 1552-5783 |
| Popis: | Purpose To elucidate the relationship between disorganization of retinal inner layers (DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with nonproliferative DR, but without diabetic macular edema (DME). Methods Fifty-seven participants with diabetes mellitus (DM) and 18 healthy controls underwent comprehensive ophthalmic examination, fundus photography, and spectral-domain optical coherence tomography. Scans of the fovea were evaluated for the presence of DRIL. Retinal function was evaluated using Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, the quick contrast sensitivity function (qCSF) on the AST Sentio Platform, short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), and frequency doubling perimetry (FDP). ANOVA and Kruskal-Wallis were used to compare retinal function in subjects with and without DRIL. Tukey-Kramer test and Wilcoxon were used for post hoc analysis. Results DRIL was identified in 9 of 57 diabetic subjects. DRIL subjects had higher body mass index and longer diabetes duration compared to diabetic subjects without DRIL (P = 0.03 and P = 0.009, respectively). Subjects with DRIL had reduced ETDRS visual acuity (P = 0.003), contrast sensitivity function (P = 0.0003), and SAP performance (PSD, P < 0.0001) compared to controls and diabetic subjects without DRIL. Structural analysis revealed inner retinal thinning, and some outer retinal thinning, associated with DRIL. Conclusions Diabetic subjects with DRIL have reduced retinal function compared to those without DRIL, and defective retinal lamination may be an early cellular consequence of diabetes responsible for this in some patients. Following further longitudinal studies, DRIL may be a readily available and reliable structural biomarker for reduced retinal function in early diabetic neuroretinal disease. |
| Databáze: | OpenAIRE |
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