Outcome after liver re-transplantation in patients with recurrent chronic hepatitis C
| Autor: | Marcus Bahra, Dietmar Jacob, Ruth Neuhaus, Ulf Neumann, Thomas Berg, Jan M. Langrehr, Peter Neuhaus |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Liver Cirrhosis Male Reoperation medicine.medical_specialty Time Factors Re transplantation Bilirubin medicine.medical_treatment Kaplan-Meier Estimate Liver transplantation Severity of Illness Index Gastroenterology Leukocyte Count chemistry.chemical_compound Postoperative Complications Chronic hepatitis Predictive Value of Tests Recurrence Internal medicine medicine Humans In patient Postoperative Period Recurrent hepatitis Hepatitis Transplantation business.industry Alanine Transaminase Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Liver Transplantation chemistry Female business |
| Zdroj: | Transplant International. 20:771-778 |
| ISSN: | 1432-2277 0934-0874 |
| Popis: | Summary Long-term outcome after liver retransplantation for recurrent hepatitis C has been reported to be inferior to other indications. The identification of factors associated which improved long-term results may help identify hepatitis C positive patients who benefit from liver retransplantation. Outcome after liver retransplantation for recurrent hepatitis C was analyzed in 18 patients (group 1) and compared with hepatitis C positive patients undergoing liver retransplantation for initial nonfunction (group 2, n = 11) and patients with liver retransplantation for other indications (group 3, n = 169). Five-year patient survival following retransplantation for groups 1, 2 and 3 was 59% 84% and 60%. Increased alanine aminotransferase (ALT) and serum bilirubin, as well as white cell count and MELD score at day of retransplantation were associated with impaired patient outcome. Five-year survival after retransplantation in patients with recurrent hepatitis C is similar to that in patients undergoing liver retransplantation for other indications. Our analysis showed MELD score, bilirubin, ALT levels and white cell counts preorthotopic liver transplantation are important predictive factors for outcome. This observational study may help select patients and identify the optimal time-point of liver retransplantation in ‘‘Hepatitis C’’ virus positive patients in the future. |
| Databáze: | OpenAIRE |
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