Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging
| Autor: | Chiara Cerami, Daniela Perani, Leonardo Iaccarino |
|---|---|
| Přispěvatelé: | Cerami, Chiara, Iaccarino, Leonardo, Perani, DANIELA FELICITA L. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty microglia activation Review Biology TSPO-PET Imaging Catalysis neuroinflammation Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Immune system Receptors GABA Alzheimer Disease medicine Dementia Humans astrocytosi Physical and Theoretical Chemistry Molecular Biology Spectroscopy Neuroinflammation Inflammation Microglia Organic Chemistry Neurodegeneration General Medicine Frontotemporal lobar degeneration Alzheimer's disease Acquired immune system medicine.disease molecular imaging astrocytosis 3. Good health Computer Science Applications 030104 developmental biology medicine.anatomical_structure neurodegenerative disorders Positron-Emission Tomography Astrocytosis neurodegenerative disorder Alzheimer’s disease 030217 neurology & neurosurgery 11C-PK11195 |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Neurodegeneration elicits neuroinflammatory responses to kill pathogens, clear debris and support tissue repair. Neuroinflammation is a dynamic biological response characterized by the recruitment of innate and adaptive immune system cells in the site of tissue damage. Resident microglia and infiltrating immune cells partake in the restoration of central nervous system homeostasis. Nevertheless, their activation may shift to chronic and aggressive responses, which jeopardize neuron survival and may contribute to the disease process itself. Positron Emission Tomography (PET) molecular imaging represents a unique tool contributing to in vivo investigating of neuroinflammatory processes in patients. In the present review, we first provide an overview on the molecular basis of neuroinflammation in neurodegenerative diseases with emphasis on microglia activation, astrocytosis and the molecular targets for PET imaging. Then, we review the state-of-the-art of in vivo PET imaging for neuroinflammation in dementia conditions associated with different proteinopathies, such as Alzheimer's disease, frontotemporal lobar degeneration and Parkinsonian spectrum. |
| Databáze: | OpenAIRE |
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