Protective effects of tea polyphenols and caffeine
| Autor: | Melissa Camouse, Edward P. Conrad, Kaija K. Hanneman, Elma D. Baron |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Chemoprotective agent
Antioxidant Skin Neoplasms Ultraviolet Rays medicine.medical_treatment Apoptosis Pharmacology Matrix Metalloproteinase Inhibitors Chemoprevention Antioxidants chemistry.chemical_compound Phenols Caffeine Ultraviolet light medicine Humans Pharmacology (medical) Carcinogen Cell Proliferation Flavonoids Neovascularization Pathologic Tea business.industry food and beverages Polyphenols medicine.disease Matrix Metalloproteinases Cell Transformation Neoplastic Oncology Biochemistry chemistry Polyphenol Health effects of natural phenols and polyphenols Skin cancer business Signal Transduction |
| Zdroj: | Expert review of anticancer therapy. 5(6) |
| ISSN: | 1744-8328 |
| Popis: | Compounds derived from botanical sources, such as polyphenols from tea, have been of interest as possible therapeutic agents. Their benefits in terms of cancer chemoprevention have also been investigated primarily through in vitro and animal in vivo studies. Ultraviolet light from solar radiation has been proven to initiate and promote skin cancer, which is the most common malignancy in light-skinned populations. This review discusses the effects of tea polyphenols in preventing cutaneous carcinogenesis. Although many of the mechanisms and pathways discussed may be applicable to other carcinogens, this review focuses mainly on those related to ultraviolet light-induced processes and potential action sites for tea polyphenols. Since caffeine is a component of tea, and has also been suggested as a possible chemoprotective agent, it is included in this review. Based on data from numerous studies published in the scientific literature, tea polyphenols are promising chemopreventive agents against ultraviolet-induced skin cancers. Their antioxidant properties, inhibitory effects on signal transduction pathways, cell proliferation, angiogenesis and capacity for apoptosis induction, as well as possible immune protective effects, are among the mechanisms that contribute to skin cancer prevention. |
| Databáze: | OpenAIRE |
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