Predictive value of titer of GAD antibodies for further progression of beta cell dysfunction in slowly progressive insulin-dependent (type 1) diabetes (SPIDDM)

Autor: Yasumichi Mori, Tetsuro Kobayashi, Masashi Ichijo, Minoru Okubo, Shoichiro Tanaka, Sayaka Ichijo, Kaoru Aida, Soichi Takizawa, Hiroki Shimura, Kaoru Nagasawa, Masahiro Kaneshige
Rok vydání: 2014
Předmět:
Zdroj: Diabetology international. 7(1)
ISSN: 2190-1678
Popis: Whether the titer of glutamic acid decarboxylase antibodies (GADAs), especially a low titer, is a marker of progression of beta cell dysfunction in patients with slowly progressive insulin-dependent (type 1) diabetes (SPIDDM) is unclear.Patients were subdivided as follows: patients with high GADA titers [≥10 U/ml (≥180 WHO U/ml): high GADA] (group 1,The proportion of patients progressing to an insulin-dependent state in groups 1, 2, 3 and 4 was significantly higher than in group 5. C-peptide responses in OGTTs of patients in groups 1 and 2 were decreased at a significantly higher rate than in group 5. Multivariate Cox proportional hazard analysis revealed that factors including high GADA, low GADA, onset age45 years, duration of diabetes24 months, body mass index (BMI)22.0 kg/mSPIDDM patients with low GADA titers have a significantly higher risk of progression to an insulin-dependent state than type 2 diabetic patients, suggesting that the presence of GADA, irrespective of the titer, is a hallmark of beta cell failure. Other risk factors for further progression to an insulin-dependent state in SPIDDM patients were ICA, onset age, duration of diabetes, BMI and residual beta cell function.
Databáze: OpenAIRE
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