Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa
| Autor: | Goran N. Kaluderovic, Sanja Grguric-Sipka, Santiago Gómez-Ruiz, Zeljko Zizak, Mohamed Al Arbi, M. Alshtewi, Zorica Juranić, Dejan Jeremić, Tibor J. Sabo |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
p-Cymene
Stereochemistry chemistry.chemical_element Crystal structure 010402 general chemistry 01 natural sciences N-methylpiperazine lcsh:Chemistry chemistry.chemical_compound ruthenium(ii) complexes Cytotoxic T cell K-3-thiosemicarbazone k3-thiosemicarbazone cytotoxic activity 010405 organic chemistry Ligand n-methylpiperazine General Chemistry Nuclear magnetic resonance spectroscopy 0104 chemical sciences Ruthenium K3-thiosemicarbazone p-cymene chemistry lcsh:QD1-999 ruthenium(II) complexes |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 73, Iss 6, Pp 619-630 (2008) Journal of the Serbian Chemical Society |
| ISSN: | 1820-7421 0352-5139 |
| Popis: | Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present. Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa. |
| Databáze: | OpenAIRE |
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