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PDF file - 338K, Supplementary Figure 1. Study design for evaluating the chemopreventive efficacy of different kava treatment regimens against NNK-induced lung adenoma formation in A/J mice. Supplementary Figure 2. Representative photomicrographs H&E-stained sections of lungs (n = 4 in each group) from negative control mice (A), mice with NNK alone (B), and mice with NNK plus kava at a dose of 5 mg/g of diet (C). Supplementary Figure 3. 1H-NMR spectra of different kava fractions and the mass balance of each fraction. I. Kava; II. Fraction A; III. Reconstituted kava from Fractions A, B, and C; IV. Fraction B; V, Comparison between Kava (Blue) and reconstituted kava (Green) from Fractions A, B, and C; VI. Fraction C; VII. Mass balance of each fraction. Supplementary Figure 4. HPLC traces of traditional kava, kava from Gaia Herbs, reconstituted kava, and Fractions A, B, and C. Supplementary Figure 5. Chemicals isolated from kava and their natural abundance. |
