Impact of ageing on muscle cell regeneration
| Autor: | Silvia Carosio, Antonio Musarò, Maria Grazia Berardinelli, Michela Aucello |
|---|---|
| Přispěvatelé: | Department of Anatomy, Histology, Forensic Medicine and Orthopedic [Roma] (DAHFMO), Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Edith Cowan University (ECU), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO)-Planning and Transport Research Centre (PATREC), The work in the authors’ laboratories has been supported by Seventh Framework Programme-Myoage, Telethon, Fondazione Roma, AIRC, AFM, MIUR and ASI., Department of Anatomy, Histology, Forensic Medicine and Orthopedic, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' [Rome] |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
MESH: Inflammation
MESH: Muscle Cells MESH: Muscles Aging Satellite Cells Skeletal Muscle Population Endogeny Biology Biochemistry 03 medical and health sciences 0302 clinical medicine medicine Myocyte Animals Humans Regeneration MESH: Aging MESH: Animals education Muscle Skeletal Molecular Biology Process (anatomy) 030304 developmental biology Inflammation 0303 health sciences education.field_of_study MESH: Muscle Skeletal Muscle Cells MESH: Humans Regeneration (biology) Muscles MESH: Regeneration MESH: Satellite Cells Skeletal Muscle Skeletal muscle aging growth factors muscle regeneration satellite cells stem cells tissue niche Cell biology medicine.anatomical_structure Neurology Immunology Basal lamina Stem cell 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Biotechnology |
| Zdroj: | Ageing Research Reviews Ageing Research Reviews; Vol 10 Ageing Research Reviews-ARR Ageing Research Reviews-ARR, Elsevier Masson, 2011, 10 (1), pp.35-42. ⟨10.1016/j.arr.2009.08.001⟩ |
| ISSN: | 1568-1637 1872-9649 |
| DOI: | 10.1016/j.arr.2009.08.001 |
| Popis: | International audience; Skeletal muscle regeneration is a coordinate process in which several factors are sequentially activated to maintain and preserve muscle structure and function. The major role in the growth, remodeling and regeneration is played by satellite cells, a quiescent population of myogenic cells that reside between the basal lamina and plasmalemma and are rapidly activated in response to appropriate stimuli. However, in several muscle conditions, including aging, the capacity of skeletal muscle to sustain an efficient regenerative pathway is severely compromised. Nevertheless, if skeletal muscle possesses a stem cell compartment it is not clear why the muscle fails to regenerate under pathological conditions. Either the resident muscle stem cells are too rare or intrinsically incapable of repairing major damage, or perhaps the injured/pathological muscle is a prohibitive environment for stem cell activation and function. Although we lack definitive answers, recent experimental evidences suggest that the mere presence of endogenous stem cells may not be sufficient to guarantee muscle regeneration, and that the presence of appropriate stimuli and factors are necessary to provide a permissive environment that permits stem cell mediated muscle regeneration and repair. In this review we discuss the molecular basis of muscle regeneration and how aging impacts stem cell mediated muscle regeneration and repair. |
| Databáze: | OpenAIRE |
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