Pretreatment body mass index as an independent prognostic factor in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy: Findings from a randomised trial
| Autor: | Xiang Guo, Cheng Tao Wang, Bi Xiu Wen, Hai Qiang Mai, Pei Yu Huang, Ming Huang Hong, Yi Shan Wu, Ling Guo, Hao Yuan Mo, Ka Jia Cao |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Mucositis Oncology Cancer Research medicine.medical_specialty Adolescent Nasopharyngeal neoplasm Kaplan-Meier Estimate Overweight Body Mass Index Young Adult Nasopharynx Internal medicine Outcome Assessment Health Care medicine Humans Aged Neoplasm Staging Proportional Hazards Models Randomized Controlled Trials as Topic business.industry Body Weight Induction chemotherapy Nasopharyngeal Neoplasms Chemoradiotherapy Leukopenia Middle Aged Prognosis medicine.disease Nasopharyngeal carcinoma Multivariate Analysis Female medicine.symptom Underweight business Body mass index |
| Zdroj: | European Journal of Cancer. 49:1923-1931 |
| ISSN: | 0959-8049 |
| Popis: | To investigate the relationship between the pretreatment body mass index (BMI) and the clinical outcomes in patients with locoregionally advanced nasopharyngeal carcinoma treated with combination of chemotherapy and radiotherapy.From August 2002 to April 2005, 400 patients with stage III or stage IVa nasopharyngeal carcinoma were recruited for a randomised clinical trial of induction chemotherapy combined with radiotherapy or concurrent chemoradiotherapy. The patients were divided into four groups of underweight (BMI18.5kg/m(2)), normal weight (BMI 18.5-22.9kg/m(2)), overweight (BMI 23.0-27.4kg/m(2)) or obese (BMI≥27.5kg/m(2)) according to the World Health Organization classifications for Asian populations. The differences in the long-term survival, of these four BMI groups were analysed.The 5-year failure-free survival rates for the underweight, normal weight, overweight and obese groups were 44%, 61%, 68% and 73%, respectively (p=0.014), and the 5-year overall survival rates were 51%, 68%, 80% and 72% (p=0.001), respectively. BMI was a strongly favoured prognostic factor of overall survival and failure-free survival in a Cox regression model.Pretreatment body mass index was a simple, reliable independent prognostic factor for patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy. |
| Databáze: | OpenAIRE |
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